Vancomycin HCL , USP level, cost: ≥900 μPermg , 1404-93-9

Synonym(s):
Vancomycin hydrochloride;Vancomycin monohydrochloride

CAS NO.：1404-93-9

Empirical Formula: C66H76Cl3N9O24

Molecular Weight: 1485.71

MDL number: MFCD03613611

EINECS: 604-193-8

PRODUCT Properties

• Melting point: >190°C (dec.)
• alpha: [α]D20 -30～-40゜ (c=1, H2O)
• Flash point: 87℃
• storage temp.: 2-8°C
• solubility: H₂O: 50 mg/mL, clear, yellow
• form: Powder
• color: colorless to faint yellow or tan
• PH: pH (50g/l, 25℃) : 2.5～4.5
• Water Solubility: Soluble in water. Slightly soluble in methanol, ethanol and dimethylsulfoxide.
• Sensitive: Hygroscopic
• Merck: 13,9995
• BRN: 3704657
• Stability: Hygroscopic

Description and Uses

Vancomycin is a glycopeptide antibiotic identified for its utility in the treatment of gram-positive bacteria, including penicillin-resistant staphylococci. It acts by binding to bacterial cell wall protein precursors, interfering with continuing protein synthesis. Vancomycin resistance in staphylococcal species has recently emerged as a clinical issue.

Vancomycin hydrochloride is the salt of a glycopeptide antibiotic isolated from Amycolatopsis orientalis in 1956. Vancomycin exhibits potent activity against Gram positive bacteria and is highly effective against MRSA in vitro and in vivo. Vancomycin interferes with cell wall synthesis by binding to D-alanine-D-alanine residues.

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H317-H334
• Precautionary statements: P261-P280-P284-P304+P340-P342+P311
• Hazard Codes: Xi
• Risk Statements: 43-42
• Safety Statements: 36/37-24/25-22-36
• WGK Germany: 2
• RTECS: YW4380000
• F: 8-10-21
• HS Code: 29419090
• Toxicity: LD50 in mice (mg/kg): 489 i.v.; 1734 i.p.; 5000 s.c.; 5000 orally (Anderson)