Tiagabine hydrochloride , ≥98%(HPLC) , 145821-59-6

Synonym(s):
(-)-(R)-1-[4,4-bis(3-methyl-2-thienyl)-3-butenyl]nipecotic acid hydrochloride;(R)-(-)-1-[4,4-Bis(3-methyl-2-thienyl)-3-butenyl]-3-piperidinecarboxylic acid hydrochloride monohydrate;(3R)-1-[4,4-Bis(3-methyl-2-thienyl)-3-buten-1-yl]-3-piperidinecarboxylic acid hydrochloride;Tiagabine hydrochloride monohydrate

CAS NO.：145821-59-6

Empirical Formula: C20H26ClNO2S2

Molecular Weight: 412.01

MDL number: MFCD07369025

EINECS: 200-659-6

PRODUCT Properties

• Melting point: >192oC dec.
• alpha: D20 -11°
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: H2O: soluble10mg/mL, clear
• pka: pKa1 3.3; pKa2 9.4(at 25℃)
• form: powder
• color: white to beige
• optical activity: [α]/D -9 to -12°, c = 1 in H2O
• Merck: 14,9417
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, ethanol, or distilled water may be stored at -20° for up to 3 months.
• InChIKey: YUKARLAABCGMCN-PKLMIRHRSA-N
• CAS DataBase Reference: 145821-59-6(CAS DataBase Reference)

Description and Uses

Tiagabine (145821-59-6) is a clinically useful anticonvulsant.1?It is also used to treat anxiety/panic disorder2?and neuropathic pain3. Tiagabine inhibits GABA-reuptake (IC50?[3H]GABA uptake = 67 nM)?via?inhibiting GABA transporter 1(GAT1) blocking both neuronal and glial GABA re-uptake.4,5

A GABA uptake inhibitor. Anticonvulsant.

Safety

• Symbol(GHS): GHS02,GHS06,GHS08
• Signal word: Danger
• Hazard statements: H225-H301+H311+H331-H370
• Precautionary statements: P210-P260-P280-P301+P310-P311
• Hazard Codes: Xn,T,F
• Risk Statements: 20/21/22-39/23/24/25-23/24/25-11
• Safety Statements: 36/37-45-16-7
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: TM6128245
• HS Code: 2934.99.3000