Tigecycline , ≥96% , 220620-09-7
Synonym(s):
9- t-Butylglycylamido-minocycline;9-t-Butylglycylamido-minocycline;9-tert-Butylglycylamidominocycline;Tigecycline;Tigecycline - CAS 220620-09-7 - Calbiochem
CAS NO.：220620-09-7
Empirical Formula: C29H39N5O8
Molecular Weight: 585.65
MDL number: MFCD00935753
EINECS: 685-736-6
| Pack Size | Price | Stock | Quantity |
| 10MG | RMB47.20 | In Stock |
|
| 50MG | RMB87.20 | In Stock |
|
| 250MG | RMB173.60 | In Stock |
|
| 1g | RMB435.20 | In Stock |
|
| 5g | RMB1759.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 164-166°C |
| Boiling point: | 890.9±65.0 °C(Predicted) |
| Density | 1.45±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C |
| solubility | Soluble in DMSO (up to at least 25 mg/ml). |
| pka | 4.50±1.00(Predicted) |
| form | Orange powder |
| color | Orange |
| Merck | 14,9432 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChIKey | FPZLLRFZJZRHSY-HJYUBDRYSA-N |
| SMILES | C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C(N(C)C)=CC(NC(CNC(C)(C)C)=O)=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O |
Description and Uses
Tigecycline is a broad-spectrum glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth. It is active against a panel of 1,924 European clinical bacterial isolates including S. aureus, S. epidermidis, S. pneumoniae, E. faecalis, E. faecium, E. coli, K. pneumoniae, P. aeruginosa, and P. mirabilis strains (MICs = <1-32 μg/ml). In vivo, tigecycline (6.25 mg/kg twice daily for 5 days) decreases levels of C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection. Formulations containing tigecycline have been used in the treatment of a variety of bacterial infections.
A broad spectrum glycylcycline antibiotic
Safety
| Symbol(GHS) |    GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H319-H360D-H372-H410 |
| Precautionary statements | P202-P260-P264-P273-P305+P351+P338-P308+P313 |
| Safety Statements | 24/25 |
| RIDADR | 3077 |
| RTECS | QI7619500 |
| HazardClass | 9 |
| PackingGroup | III |
| HS Code | 29419090 |
