Tigecycline , ≥96% , 220620-09-7

Synonym(s):
9- t-Butylglycylamido-minocycline;9-t-Butylglycylamido-minocycline;9-tert-Butylglycylamidominocycline;Tigecycline;Tigecycline - CAS 220620-09-7 - Calbiochem

CAS NO.：220620-09-7

Empirical Formula: C29H39N5O8

Molecular Weight: 585.65

MDL number: MFCD00935753

EINECS: 685-736-6

PRODUCT Properties

• Melting point: 164-166°C
• Boiling point: 890.9±65.0 °C(Predicted)
• Density: 1.45±0.1 g/cm3(Predicted)
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: Soluble in DMSO (up to at least 25 mg/ml).
• pka: 4.50±1.00(Predicted)
• form: Orange powder
• color: Orange
• Merck: 14,9432
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
• InChIKey: FPZLLRFZJZRHSY-HJYUBDRYSA-N
• SMILES: C1(=O)[C@]2(O)[C@@]([H])(C[C@@]3([H])C(=C2O)C(=O)C2=C(C(N(C)C)=CC(NC(CNC(C)(C)C)=O)=C2O)C3)[C@H](N(C)C)C(O)=C1C(N)=O
• CAS DataBase Reference: 220620-09-7(CAS DataBase Reference)

Description and Uses

Tigecycline is a broad-spectrum glycylcycline antibiotic that binds to the bacterial 30S ribosome, blocking the entry of transfer RNA, which halts protein synthesis and inhibits bacterial growth. It is active against a panel of 1,924 European clinical bacterial isolates including S. aureus, S. epidermidis, S. pneumoniae, E. faecalis, E. faecium, E. coli, K. pneumoniae, P. aeruginosa, and P. mirabilis strains (MICs = <1-32 μg/ml). In vivo, tigecycline (6.25 mg/kg twice daily for 5 days) decreases levels of C. difficile cytotoxin activity and spore formation in cecum and colon in a mouse model of C. difficile infection. Formulations containing tigecycline have been used in the treatment of a variety of bacterial infections.

A broad spectrum glycylcycline antibiotic

Safety

• Symbol(GHS): GHS07,GHS08,GHS09
• Signal word: Danger
• Hazard statements: H319-H360D-H372-H410
• Precautionary statements: P202-P260-P264-P273-P305+P351+P338-P308+P313
• Safety Statements: 24/25
• RIDADR: 3077
• RTECS: QI7619500
• HazardClass: 9
• PackingGroup: III
• HS Code: 29419090
• Hazardous Substances Data: 220620-09-7(Hazardous Substances Data)