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A7828912

Tolazamide , ≥96%(T) , 1156-19-0

Synonym(s):
1-(Hexahydro-1H-azepin-1-yl)-3-(p-toluenesulfonyl)urea

CAS NO.:1156-19-0

Empirical Formula: C14H21N3O3S

Molecular Weight: 311.4

MDL number: MFCD00083504

EINECS: 214-588-3

Pack Size Price Stock Quantity
250MG RMB399.20 In Stock
1G RMB1039.20 In Stock
5g RMB3199.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 162-164°C
Boiling point: 300°C (rough estimate)
Density  1.2228 (rough estimate)
refractive index  1.6740 (estimate)
storage temp.  Sealed in dry,Room Temperature
solubility  Very slightly soluble in water; freely soluble in chloroform; soluble in acetone; slightly soluble in ethanol (96%).
form  Solid
pka 3.6(at 25℃)
color  White to Off-White
Water Solubility  65.4mg/L(30 ºC)
CAS DataBase Reference 1156-19-0(CAS DataBase Reference)
EPA Substance Registry System Tolazamide (1156-19-0)

Description and Uses

Tolazamide is a first generation sulfonylurea that inhibits sulfonylurea receptor 1 (SUR1) linked to the inwardly rectifying potassium channel (KIR6.2; IC50 = 4.2 μM in HEK293 cells transfected with the human receptor). It has no effect on glucose uptake in L6 rat skeletal muscle cells when used at a concentration of 0.6 mg/mL but enhances glucose uptake two-fold when used in combination with insulin. In vivo, tolazamide (128 mg/kg) reduces glomerulosclerosis and albumin excretion in a rat model of insulin-dependent diabetes induced by streptozotocin . Formulations containing tolazamide have been used in the treatment of type 2 diabetes.

This drug is also a derivative of first generation of sulfonylurea, and it possesses stimulatory action on β-cells in pancreas, as well as the same range of action as all other drugs of the group of examined compounds. Tolazamide is used for non-insulin-dependent diabetes mellitus without expressed microvascular complications.

Safety

Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H370
Precautionary statements  P260-P264-P270-P307+P311-P321-P405-P501
Hazard Codes  Xn
Risk Statements  22
Safety Statements  36
WGK Germany  3
RTECS  YT4400000
HS Code  2935904000
Hazardous Substances Data 1156-19-0(Hazardous Substances Data)
Toxicity LD50 in rats, mice (mg/kg): >5000 orally, 2239 i.p. (Dulin)

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