Pioglitazone Hydrochloride , 98% , 112529-15-4

Synonym(s):
5-[[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]phenyl]methyl]-2,4-thiazolidinedione monohydrochloride;5-[4-[2-(5-Ethyl-2-pyridinyl)ethoxy]benzyl]thiazolidine-2,4-dione hydrochloride;Pioglitazone hydrochloride

CAS NO.：112529-15-4

Empirical Formula: C19H21ClN2O3S

Molecular Weight: 392.9

MDL number: MFCD04975446

EINECS: 629-731-9

PRODUCT Properties

• Melting point: 193-194°C
• RTECS: XJ5813440
• storage temp.: 2-8°C
• solubility: DMSO: ≥10mg/mL
• form: powder
• color: white to off-white
• Water Solubility: Soluble in water (<1 mg/ml at 25°C), DMF, methanol, ethanol (4 mg/ml at 25°C), and DMSO (79 mg/ml at 25°C).
• Merck: 14,7452
• BCS Class: 2
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: GHUUBYQTCDQWRA-UHFFFAOYSA-N
• CAS DataBase Reference: 112529-15-4(CAS DataBase Reference)

Description and Uses

Pioglitazone is a new orally active thiazolidinedione (TZD) launched in the US for the treatment of non-insulin dependent diabetes mellitus (NIDDM). It can be synthesized in 4 steps, the last one transforming an alphabromoester into thiazolidine with thiourea. As with other representatives in this class, it potently activates the nuclear receptor peroxisome proliferator-activated receptor gamma which is believed to be involved in the regulation of insulin resistance and adipogenesis. In several obese and obese diabetic animal models, treatment with Pioglitazone resulted in reductions in plasma glucose and serum lipids. In clinical studies, Pioglitazone at a once daily oral dose of 15-45 mg, as monotherapy or in combination with non-TZDs or insulin, was shown to significantly improve glycemic control in type-2 diabetes and demonstrated a beneficial effect on insulin resistance and other clinically relevant parameters as plasma levels of triglycerides or HDL-cholesterol. Pioglitazone is reported to be safe and well tolerated and is said to have a lower occurrence of hepatic toxicity as well as a low probability for drug interaction.

Pioglitazone Hydrochloride is used as an antidiabetic.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H319
• Precautionary statements: P264-P280i-P305+P351+P338-P337+P313
• Hazard Codes: Xi
• Risk Statements: 36/38-36
• Safety Statements: 22-24/25-26
• WGK Germany: 3
• HazardClass: IRRITANT
• HS Code: 29341000