A0776212
17-AAG , 98% , 75747-14-7
Synonym(s):
17-(Allylamino)geldanamycin;17-AAG;17-Demethoxy-17-allylamino geldanamycin;Geldanamycin,17-demethoxy-17-(2-propenylamino)-;Tanespimycin
| Pack Size | Price | Stock | Quantity |
| 5mg | RMB155.20 | In Stock |
|
| 25MG | RMB628.00 | In Stock |
|
| 100MG | RMB1919.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 201-203°C |
| Boiling point: | 797.8±60.0 °C(Predicted) |
| Density | 1.21 |
| RTECS | LX8932000 |
| Flash point: | >110°(230°F) |
| storage temp. | Keep in dark place,Sealed in dry,Store in freezer, under -20°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 8.62±0.70(Predicted) |
| color | Purple or dark red |
| Water Solubility | Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water |
| Sensitive | Light Sensitive |
| Stability: | Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
Description and Uses
17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable.
17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H317 |
| Precautionary statements | P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 22-24/25-36-26 |
| WGK Germany | 3 |
| HS Code | 29419090 |
