Home Categories API 17-AAG
A0776212

17-AAG , 98% , 75747-14-7

Synonym(s):
17-(Allylamino)geldanamycin;17-AAG;17-Demethoxy-17-allylamino geldanamycin;Geldanamycin,17-demethoxy-17-(2-propenylamino)-;Tanespimycin

CAS NO.:75747-14-7

Empirical Formula: C31H43N3O8

Molecular Weight: 585.69

MDL number: MFCD04973892

Pack Size Price Stock Quantity
5mg RMB155.20 In Stock
25MG RMB628.00 In Stock
100MG RMB1919.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 201-203°C
Boiling point: 797.8±60.0 °C(Predicted)
Density  1.21
RTECS  LX8932000
Flash point: >110°(230°F)
storage temp.  Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility  DMSO: soluble
form  solid
pka 8.62±0.70(Predicted)
color  Purple or dark red
Water Solubility  Soluble in DMSO at 150 mg/mL; soluble in ethanol at 5 mg/mL. Very poorly soluble in water
Sensitive  Light Sensitive
Stability: Stable for 1 year from date of purchase as supplied. Protect from moisture. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey AYUNIORJHRXIBJ-HTLBVUBBSA-N
SMILES C12C(=O)C(=CC(=O)C=1NCC=C)NC(=O)C(C)=CC=C[C@H](OC)[C@@H](OC(=O)N)C(C)=C[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C2 |t:17,19,30|
CAS DataBase Reference 75747-14-7

Description and Uses

17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable.

17-(Allylamino)-17-demethoxygeldanamycin (17-AAG) inhibits heat shock protein 90 (Hsp90), the expression of heat shock factor-1, and the activity of oncogenic proteins such as N-ras, Ki-ras, c-Akt, and p185erB2. In addition to its anti-tumor effects, 17-AAG also induces apoptosis.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H317
Precautionary statements  P501-P261-P272-P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P333+P313
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  22-24/25-36-26
WGK Germany  3
HS Code  29419090

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