NVP-AUY922 , ≥98% , 747412-49-3
Pack Size | Price | Stock | Quantity |
5MG | RMB221.60 | In Stock |
|
10MG | RMB415.20 | In Stock |
|
25MG | RMB799.20 | In Stock |
|
50mg | RMB1438.40 | In Stock |
|
100MG | RMB1615.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 180-184°C |
Boiling point: | 640.1±55.0 °C(Predicted) |
Density | 1.234 |
storage temp. | -20°C |
solubility | Soluble in DMSO (>25 mg/ml) |
form | solid |
pka | 8.47±0.48(Predicted) |
color | White |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
CAS DataBase Reference | 747412-49-3 |
Description and Uses
Hsp90 is a molecular chaperone of many different kinases, transcription factors, and hormone receptors involved in signal transduction, cell cycle regulation, and apoptosis. In addition to its important function in normal cell homeostasis, a high affinity form of Hsp90 is prevalent in tumor cells. Hsp90 inhibition has been associated with the degradation of oncogenic client proteins. NVP-
NVP-AUY 922 is a potent inhibitor of heat shock protein 90 (Hsp90) that prevents the proliferation of a range of human cancer cell lines. NVP-AUY 922 has been shown to enhance the radiation sensitivity of tumor cell lines under hypoxia. Potent Hedgehog inhibitor.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P271-P280 |
HS Code | 2934999090 |