Ticagrelor , ≥98% , 274693-27-5

CAS NO.：274693-27-5

Empirical Formula: C23H28F2N6O4S

Molecular Weight: 522.57

MDL number: MFCD09954148

EINECS: 619-540-9

PRODUCT Properties

• Melting point: 138-140°C
• Boiling point: 777.6±70.0 °C(Predicted)
• Density: 1.67
• storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• solubility: Methanol (Slightly)
• pka: 13.26±0.70(Predicted)
• form: Solid
• color: White to Off-White
• Stability: Hygroscopic
• InChIKey: OEKWJQXRCDYSHL-FNOIDJSQSA-N
• SMILES: [C@@H]1(O)[C@@H](OCCO)C[C@@H](N2C3C(N=N2)=C(N[C@@H]2C[C@H]2C2=CC=C(F)C(F)=C2)N=C(SCCC)N=3)[C@@H]1O

Description and Uses

Ticagrelor is a reversible antagonist of the platelet purinergic P2Y₁₂ receptor (K_i = 14 nM; IC₅₀ = 1.8 μM), which is the main receptor responsible for ADP-induced platelet aggregation. It functions by directly changing the conformation of the P2Y₁₂ receptor to inhibit ADP binding. Formulations containing ticagrelor have been used to reduce the rate of thrombotic cardiovascular events in patients with acute coronary syndrome.

Ticagrelor, the first reversible oral P2Y12 receptor antagonist, provides faster, greater, and more consistent ADP-receptor inhibition than Clopidogrel. Used in the treatment of acute coronary syndromes (ACS).

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H319-H411
• Precautionary statements: P264-P280-P305+P351+P338-P337+P313P
• Safety Statements: 24/25
• HS Code: 29335990