(S)-Methyl2-(2-chlorophenyl)-2-(6,7-dihydrothieno[3,2-c]pyridin-5(4H)-yl)acetate , 98% , 113665-84-2

CAS NO.：113665-84-2

Empirical Formula: C16 H16 Cl N O2 S

Molecular Weight: 321.82

MDL number: MFCD05662337

EINECS: 601-269-2

PRODUCT Properties

• alpha: D20 +51.52° (c = 1.61 in methanol)
• Boiling point: 423.7±45.0 °C(Predicted)
• Density: 1.317±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 50mg/ml in DMSO
• form: Oil
• pka: 4.56±0.20(Predicted)
• color: Colorless to light yellow
• InChI: InChI=1/C16H16ClNO2S/c1-20-16(19)15(12-4-2-3-5-13(12)17)18-8-6-14-11(10-18)7-9-21-14/h2-5,7,9,15H,6,8,10H2,1H3/t15-/s3
• InChIKey: GKTWGGQPFAXNFI-UJHUVDBMNA-N
• SMILES: [C@@H](C1C=CC=CC=1Cl)(N1CCC2SC=CC=2C1)C(=O)OC |&1:0,r|
• CAS DataBase Reference: 113665-84-2(CAS DataBase Reference)

Description and Uses

Clopidogrel was launched in the US as a potent inhibitor of platelet aggregation for the preventive management of secondary ischemic events, including MI, stroke and vascular deaths. Clopidogrel can be synthesized in 4 steps (including an optical resolution to the S active enantiomer) from 2-(2- ch1orophenyl)-glycine, the key step being the cyclization to thienopyridine with formaldehyde and acetic acid. Clopidogrel belongs to the original chemical class of Ticlopidine, but shows fewer side effects (in particular, bone-marrowsuppressing effects) at the dosage generally used. Like Ticlopidine, it is an Adenosine diphosphate (ADP) antagonist acting at the purinergic P2y receptor. In in vivo experiments with rabbits, Clopidogrel shows a maximal antiaggregant effect at 20mg/kg po, reducing adhesion of platelets to the vascular subendothelium ; moreover, it reduces myointimal thickening occuring after endothelial injury of rat carotid artery. Clopigrel does not affect platelet aggregation in vitro ; actually, its in vivo activity is highly dependent on hepatic metabolism. The results of a CAPRIE trial (Clopidogrel versus Aspirin in patients at risk of ischemic events) demonstrated that Clopidogrel was well tolerated and more effective than aspirin.

Sertraline metabolite

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26-36
• Hazardous Substances Data: 113665-84-2(Hazardous Substances Data)