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A7783412

Terbutaline solution , 1.00mg/ml , 23031-32-5

Synonym(s):
2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol;5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt;Terbutaline hemisulfate salt

CAS NO.:23031-32-5

Empirical Formula: C24H40N2O10S

Molecular Weight: 548.65

MDL number: MFCD00079584

EINECS: 245-386-3

Pack Size Price Stock Quantity
1ML RMB511.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 246-248°C
Density  1.1840 (rough estimate)
refractive index  1.6900 (estimate)
storage temp.  2-8°C
solubility  H2O: soluble100mg/mL, clear to slightly hazy, colorless to yellow
pka pKa1 8.8, pKa2 10.1, pKa3 11.2(at 25℃)
form  Solid
color  White to Off-White
InChI InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
InChIKey KFVSLSTULZVNPG-UHFFFAOYSA-N
SMILES C1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.C1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.S(=O)(=O)(O)O

Description and Uses

Terbutaline is the N-t-butyl analogue of metaproterenol and, as such, would be expected to have a more potent β2-selectivity. When compared to metaproterenol, terbutaline has a threefold greater potency at the β2-receptor. Like metaproterenol, it is resistant to COMT and slowly metabolized by MAO, therefore having good oral bioavailability with similar onset and duration. Terbutaline is available as tablets and solutions for injection and inhalation. Adverse effects are similar to other direct-acting β2-selective agonists, however, with a greater incidence of palp

Anti Asthmatic

Safety

Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H361
Precautionary statements  P280
Hazard Codes  Xn
Risk Statements  42/43-63
Safety Statements  26-36
WGK Germany  3
RTECS  DN9000000
HS Code  2922504500
Toxicity dog,LD50,intravenous,116mg/kg (116mg/kg),Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 757, 1972.

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