ZSTK474 , ≥98% , 475110-96-4

CAS NO.：475110-96-4

Empirical Formula: C19H21F2N7O2

Molecular Weight: 417.41

MDL number: MFCD08705334

PRODUCT Properties

• Melting point: 217-219 °C(Solv: ethanol (64-17-5))
• Boiling point: 640.3±65.0 °C(Predicted)
• Density: 1.57
• storage temp.: -20°C
• solubility: Soluble in DMSO (up to 20 mg/ml) or in Ethanol (up to 2.5 mg/ml with warming).
• form: White powder.
• pka: 5.21±0.10(Predicted)
• color: White or off-white
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

Description and Uses

ZSTK474 (475110-96-4) is a novel Class I phosphatidylinositol 3-kinase (PI3K) inhibitor. ZSTK474 is an ATP-competitive inhibitor of all four Class I PI3K isoforms. However, it inhibits PI3Kδ most potently, with a Ki of 1.8 nM, while inhibiting the α, β and γ isoforms at slightly higher concentrations (6.7 nM, 10.4 nM and 11.7 nM, respectively)1. Displays potent antitumor activity against human cancer xenografts (A549, PC-3 and WiDr) when administered to mice2. ZSTK474 displays potent anti-inflammatory activity via modulation of human CD14+ monocyte-derived dendritic cell functions and suppresses experimental autoimmune encephalomyelitis3. Ameliorates the progression of adjuvant-induced arthritis in a rat model4.

ZSTK474 is an ATP-competitive inhibitor of class I phosphatidylinositol 3 kinase (PI3K) isoforms. Potent PI3K inhibitor.

Safety

• HS Code: 29349990