Terbutaline , ≥98% , 23031-25-6

CAS NO.：23031-25-6

Empirical Formula: C12H19NO3

Molecular Weight: 225.28

MDL number:

EINECS: 245-385-8

PRODUCT Properties

• Melting point: 119-122°
• Boiling point: 366.8°C (rough estimate)
• Density: 1.0951 (rough estimate)
• refractive index: 1.4596 (estimate)
• storage temp.: Refrigerator
• solubility: DMSO (Slightly), Methanol (Slightly)
• form: Solid
• pka: pKa 8.70(H2O t = 25 I = 0.01) (Uncertain);10.09(H2O t = 25 I = 0.01) (Uncertain)
• color: White to Off-White

Description and Uses

Terbutaline is a synthetic congener of adrenaline that acts at the β2-receptor causing bronchodilation and tocolytic effects. It was the first β2-selective adrenoreceptor agonist in general clinical use. In 2011, the Food and Drug Administration (FDA) placed a black-boxed warning on terbutaline stating that terbutaline injections should not be given to pregnant women nor should be used to prevent preterm labor or for long-term (greater than 48–72 h) treatment of preterm labor. Oral terbutaline should not be used at all due to its potential for cardiac toxicity and death. Terbutaline is on the World Anti- Doping Agency’s list of prohibited drugs for Olympic athletes (except when a Therapeutic Use Exemption has been granted in advance and when used by inhalation).

Terbutaline is a beta-adrenoceptor agonist used to treat asthma and premature labor.

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H373-H361
• Precautionary statements: P260-P314-P501-P201-P202-P281-P308+P313-P405-P501