A7767158
Folinicacidcalciumsalthydrate , 10mMinWater , 1492-18-8
Synonym(s):
Calcium folinate;Folinic acid calcium salt;Folinic acid calcium salt hydrate;Leucovorin calcium salt;Citrovorum factor calcium salt
CAS NO.：1492-18-8
Empirical Formula: C20H25CaN7O7
Molecular Weight: 515.54
MDL number: MFCD00006704
EINECS: 216-082-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | >300°C |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Sparingly soluble in water, practically insoluble in acetone and in ethanol (96 per cent). |
| form | powder |
| color | Pale Yellow to Light Yellow |
| BRN | 5723924 |
| BCS Class | 1 |
| Stability: | Hygroscopic |
| InChIKey | SFFPBUMPHJUNTG-OKWBDBCSNA-N |
| SMILES | C(N1C(CNC2NC(N)=NC(=O)C1=2)CNC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1)=O.[Ca] |&1:22,r| |
| LogP | -3.187 (est) |
| CAS DataBase Reference | 1492-18-8(CAS DataBase Reference) |
Description and Uses
Calcium folinate offsets the effects of folic acid antagonists that act by binding dihydrofolate reductase and blocking the conversion of folic acid to tetrahydrofolate. In medicine, calcium folinate is used after treatment with methotrexate to reduce the toxicity of the methotrexate. Calcium folinate is also used to enhance the cytotoxic effect of 5-fluorouracil in the treatment of cancer.
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H315-H317-H319-H334-H335 |
| Precautionary statements | P261-P264-P280-P302+P352-P304+P340+P312-P305+P351+P338 |
| Hazard Codes | Xn |
| Risk Statements | 36/37/38-42/43 |
| Safety Statements | 26-36-36/37-22-45 |
| WGK Germany | 3 |
| RTECS | MA0600500 |
| F | 3-8-10-23 |
| HS Code | 29362900 |
