2,4,5-Trichloropyrimidine , 98% , 5750-76-5

CAS NO.：5750-76-5

Empirical Formula: C4HCl3N2

Molecular Weight: 183.42

MDL number: MFCD03788200

EINECS: 628-281-0

PRODUCT Properties

• Boiling point: 84°C 1mm
• Density: 1.6001 g/mL at 25 °C (lit.)
• refractive index: n20/D 1.574(lit.)
• Flash point: >230 °F
• storage temp.: Inert atmosphere,Store in freezer, under -20°C
• pka: -4.26±0.29(Predicted)
• form: clear liquid
• color: Colorless to Light orange to Yellow
• Water Solubility: Not miscible or difficult to mix in water.
• BRN: 4449
• InChI: InChI=1S/C4HCl3N2/c5-2-1-8-4(7)9-3(2)6/h1H
• InChIKey: GIKMWFAAEIACRF-UHFFFAOYSA-N
• SMILES: C1(Cl)=NC=C(Cl)C(Cl)=N1

Description and Uses

2,4,5-Trichloropyrimidine is used in the synthesis of potent and selective anaplastic lymphoma kinase (ALK-5) inhibitors, used as an anti-tumor treatment. Also used in the synthesis of EGFR inhibitors.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: 3267
• WGK Germany: 3
• Hazard Note: Irritant
• HazardClass: 8
• PackingGroup: III
• HS Code: 29335990