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S3716251

anhydrous,containsamylenesasstabilizer,≥99% , 67-66-3

Synonym(s):
Methylidyne trichloride;TCM, Trichloromethane, Methane trichloride, Methyl trichloride;Trichloromethane;Trichloromethane, Chloroform;Trichloromethane, FM approval

CAS NO.:67-66-3

Empirical Formula: CHCl3

Molecular Weight: 119.38

MDL number: MFCD00000826

EINECS: 200-663-8

Update time: 2022-07-08

PRODUCT Properties

Melting point: -63 °C
Boiling point: 61 °C
Density  1.492 g/mL at 25 °C(lit.)
vapor density  4.1 (vs air)
vapor pressure  160 mm Hg ( 20 °C)
refractive index  n20/D 1.445(lit.)
Flash point: 60.5-61.5°C
storage temp.  2-8°C
solubility  Miscible with diethyl ether, oils, ligroin, alcohol, carbon tetrachloride and carbon disulfide.
pka 15,5(at 25℃)
form  Liquid
color  ≤10(APHA)
Relative polarity 0.259
Odor Ethereal, sweet odor detectable at 133 to 276 ppm (mean = 192 ppm)
Odor Threshold 3.8ppm
Water Solubility  8 g/L (20 ºC)
λmax λ: 245 nm Amax: 1.00
λ: 255 nm Amax: 0.15
λ: 260 nm Amax: 0.15
λ: 270 nm Amax: 0.02
λ: 290-400 nm Amax: 0.01
Merck  14,2141
BRN  1731042
Henry's Law Constant 1.07 at 2 °C, 1.49 at 6 °C, 1.79 at 10 °C, 3.02 at 18 °C, 4.02 at 25 °C, 5.20 at 30 °C, 7.60 at 40 °C, 11.1 at 50 °C, 14.8 at 60 °C (EPICS-SPME-GC, G?rgényi et al., 2002))
Exposure limits Potential occupational carcinogen. NIOSH REL: STEL (1 h) 2 ppm (9.78 mg/m3), IDLH 500 ppm; OSHA PEL: ceiling 50 ppm (240 mg/m3); ACGIH TLV: TWA 10 ppm (adopted).
Dielectric constant 5.5(0℃)
Stability: Volatile
LogP 1.970

Description and Uses

Chloroform is a trichlorinated organic substance with the chemical formula of CHCl3. It is a clear liquid at room temperature and has a pleasant, sweet odor. Chloroform is only slightly soluble in water and evaporates quickly into surrounding air, increasing the risk of inhalation exposure. In addition, chloroform persists for a long time in both water and air. There are no natural sources of chloroform, but this contaminant enters the environment through a variety of industrial operations, including the chlorination of water. Humans can be exposed to chloroform through inhalation, ingestion, and dermal contact.
Chloroform has a relatively narrow margin of safety and has been replaced by better inhalation anesthetics. In addition, it is believed to be toxic to the liver and kidneys and may cause liver cancer. Chloroform was once widely used as a solvent, but safety and environmental concerns have reduced this use as well. Nevertheless, chloroform has remained an important industrial chemical.

Chloroform is a widely used industrial and laboratory solvent. It is a volatile chlorinated organic solvent whose vapors have a narcotic effect.Due to its light sensitivity, it may undergo degradation with time. This can be suppressed by adding ethanol as a stabilizer. The addition will increase the polarity of the solvent and potentially impact certain applications.

  1. Chloroform has been used as a solvent for dissolving lipids and also as a cleansing agent.
  2. It may also be used in solvent extraction process and also for recrystallization.
  3. Suitable for HPLC, spectrophotometry, environmental testing
  4. Facilitates recovery of the aqueous phase of PCRs which have been overlaid with mineral oil.
  5. Meets ACS specifications.

Safety

Symbol(GHS) 
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H319-H336-H351-H361d-H373
Precautionary statements  P202-P210-P233-P240-P305+P351+P338-P308+P313
Hazard Codes  Xn,F,T,Xi
Risk Statements  45-46-11-23/24/25-36/37/38-48/20/22-40-38-22-67-66-36/38-41-37/38-39/23/24/25-20-63-20/22-36-48/20
Safety Statements  9-16-26-36-36/37-45-36/37/39-25-23-53-33-7
OEL STEL: 2 ppm (9.78 mg/m3) [60-minute]
RIDADR  UN 1888 6.1/PG 3
WGK Germany  3
RTECS  FS9100000
TSCA  Yes
HazardClass  6.1
PackingGroup  III
HS Code  29031300
Toxicity LD50 (14 day) orally in rats: 2.18 ml/kg (Smyth); 0.9 ml/kg (Kimura)
IDLA 500 ppm

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