2,3,5,6-Tetramethylpyrazine , 98% , 1124-11-4
CAS NO.：1124-11-4
Empirical Formula: C8H12N2
Molecular Weight: 136.19
MDL number: MFCD00006146
EINECS: 214-391-2
| Pack Size | Price | Stock | Quantity |
| 5G | RMB23.20 | In Stock |
|
| 25G | RMB64.00 | In Stock |
|
| 100G | RMB198.40 | In Stock |
|
| 500G | RMB740.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 77-80 °C(lit.) |
| Boiling point: | 190 °C(lit.) |
| Density | 1.08 |
| FEMA | 3237 | 2,3,5,6-TETRAMETHYLPYRAZINE |
| refractive index | 1.5880 (estimate) |
| Flash point: | 128-130°C/200mm |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | 4g/l |
| pka | 3.20±0.10(Predicted) |
| form | Solid |
| color | White to Off-White |
| Odor | at 10.00 % in dipropylene glycol. nutty musty chocolate coffee cocoa brown lard burnt |
| Odor Type | nutty |
| Water Solubility | Soluble in water (4 g/L at 20°C). |
| JECFA Number | 780 |
| BRN | 113100 |
| Stability: | Stable. Incompatible with strong acids, strong oxidizing agents. |
| InChIKey | FINHMKGKINIASC-UHFFFAOYSA-N |
| LogP | 1.56 |
| CAS DataBase Reference | 1124-11-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Pyrazine, tetramethyl-(1124-11-4) |
| EPA Substance Registry System | Tetramethylpyrazine (1124-11-4) |
Description and Uses
2,3,5,6-Tetramethylpyrazine is an alkaloid that has been found in L. wallichii and has diverse biological activities. It reduces kainate-induced increases in production of reactive oxygen species (ROS) and cytotoxicity in primary rat hippocampal neurons when used at a concentration of 5 μM. 2,3,5,6-Tetramethylpyrazine (0.1 mM) induces vasodilation in precontracted isolated and endothelium-denuded rat tail artery strips and reduces blood pressure in anesthetized rats. It decreases infarct volume, caspase-3 activation, and hypoxia-inducible factor-1α (HIF-1α) levels in a rat model of focal cerebral ischemia induced by middle cerebral artery occlusion (MCAO) when administered at a dose of 20 mg/kg.
etramethylpyrazine is an anti-inflammatory compound isolated from the fermented food natto. Tetramethylpyrazine demonstrated in vivo nootropic activity in rats.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P301+P312-P302+P352-P305+P351+P338 |
| Hazard Codes | Xn,Xi |
| Risk Statements | 22-37/38-41-36/37/38 |
| Safety Statements | 26-39-24/25-37/39-36 |
| WGK Germany | 3 |
| RTECS | UQ3905000 |
| TSCA | Yes |
| HS Code | 29339990 |
