Estriol , Analysis standard , 50-27-1

Synonym(s):
1,3,5(10)-Estratriene-3,16α,17β-triol;16α-Hydroxyestradiol;3,16α,17β-Trihydroxy-1,3,5(10)-estratriene;Estriol

CAS NO.：50-27-1

Empirical Formula: C18H24O3

Molecular Weight: 288.38

MDL number: MFCD00003691

EINECS: 200-022-2

PRODUCT Properties

• Melting point: 280-282 °C(lit.)
• alpha: D25 +58° ±5° (0.04 g in 1 ml dioxane)
• Boiling point: 370.61°C (rough estimate)
• Density: 1.27
• refractive index: 58 ° (C=0.4, Dioxane)
• Flash point: 9℃
• storage temp.: 2-8°C
• solubility: Practically insoluble in water, sparingly soluble in ethanol (96 per cent).
• form: Solid
• pka: pKa 10.38±0.02(H2O t=23±2 Iunspeci?ed) (Uncertain)
• color: White to Off-White
• optical activity: +6127 (95% ethanol)
• Water Solubility: 3.2mg/L(25 ºC)
• Merck: 3707
• BRN: 2508172
• InChIKey: PROQIPRRNZUXQM-ZXXIGWHRSA-N
• CAS DataBase Reference: 50-27-1(CAS DataBase Reference)
• NIST Chemistry Reference: Estriol(50-27-1)
• EPA Substance Registry System: Estriol (50-27-1)

Description and Uses

Estriol is significantly less active than estradiol; however, it has a selective ability to stimulate blood flow and restoration of genital epithelium. In addition, using this drug reduces mental symptoms of menopausal syndrome. It is used in the premenopausal and menopausal periods, for skin atrophy and signs of genital degeneration, and so on.

A metabolite of Estradiol (E888000). An estrogenic metabolite considerably less potent than the hormone Estradiol (E888000).

Safety

• Symbol(GHS): GHS08
• Signal word: Danger
• Hazard statements: H351-H360FD-H362
• Precautionary statements: P201-P202-P260-P263-P264-P308+P313
• Hazard Codes: T,F
• Risk Statements: 60-61-40-45-39/23/24/25-23/24/25-11
• Safety Statements: 53-22-36/37/39-45-36/37-16
• RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution
• WGK Germany: 3
• RTECS: KG8225000
• F: 8-10
• HS Code: 29072990
• Hazardous Substances Data: 50-27-1(Hazardous Substances Data)
• Toxicity: LD50 oral in rat: > 2gm/kg