A7704912
Timosaponin A-Ⅲ , Analysis of standard products, ≥98% , 41059-79-4
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB398.40 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 317-322 °C |
| Boiling point: | 862.8±65.0 °C(Predicted) |
| Density | 1.36±0.1 g/cm3(Predicted) |
| solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml |
| form | White to off white solid. |
| pka | 12.85±0.70(Predicted) |
| color | White to off-white |
Description and Uses
Timosaponin A3 suppresses certain human tumor processes and has the potential to be developed as an anticancer agent. Reverses multi-drug resistance in human chronic myelogenous leukemia K562/ADM cells via downregulation of MDR1 and MRP1 expression by inhibiting PI3K/Akt signaling pathway. Induction of mitochondrial-dependent apoptosis in HepG2 human hepatocellular carcinoma cells.Timosaponin A3 is a potent inhibitor of U46619, that induces rat platelet aggregation and exhibited superior selectivity for the TP receptor vs. other G protein-coupled receptors and a PKC activator.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P280-P305+P351+P338 |
