Baicalin , 95% , 21967-41-9
Synonym(s):
5,6-Dihydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl-β-D-glucopyranosiduronic acid;Baicalein 7-β-D -glucopyranosiduronate;Baicalein 7-O-β-D -glucuronide
CAS NO.：21967-41-9
Empirical Formula: C21H18O11
Molecular Weight: 446.36
MDL number: MFCD00149302
EINECS: 606-866-1
| Pack Size | Price | Stock | Quantity |
| 1G | RMB250.40 | In Stock |
|
| 5G | RMB1215.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 202-205 °C (dec.) (lit.) |
| alpha | -85 º (c=1, DMSO) |
| Boiling point: | 836.6±65.0 °C(Predicted) |
| Density | 1.737±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | solid |
| pka | 2.72±0.70(Predicted) |
| color | Pale Yellow to Yellow |
| optical activity | [α]20/D 85°, c = 1 in DMSO |
| Stability: | Hygroscopic |
| InChIKey | IKIIZLYTISPENI-ZFORQUDYSA-N |
| SMILES | OC1C(=C(O[C@H]2[C@@H]([C@@H](O)[C@H](O)[C@@H](C(=O)O)O2)O)C=C2OC(C3C=CC=CC=3)=CC(=O)C=12)O |&1:5,6,7,9,11,r| |
| LogP | 1.431 (est) |
Description and Uses
Baicalin is a flavonoid that has been found in S. baicalensis and has diverse biological activities. It reduces myocardial apoptosis and increases cardiac microvessel levels of endothelial nitric oxide synthase (eNOS) in a rat model of ischemia-reperfusion injury when administered at doses of 30 and 100 mg/kg. Baicalin (50 and 80 mg/kg) increases the number of intratumor CD8+ T cells and reduces tumor volume in an H22 murine hepatocellular carcinoma model. It reduces LPS-induced cortical production of reactive oxygen species (ROS) and levels of IL-1β and TNF-α in a mouse model of neuroinflammation. Baicalin decreases body weight, increases the number of rats with regular estrous cycles, and ameliorates follicular development in a mouse model of dehydroepiandrosterone-induced polycystic ovary syndrome (PCOS). It also decreases immobility time in the forced swim test in a mouse model of depression induced by chronic mild stress.
diuretic, prolyl endopeptidase inhibitor, antineoplastic
