Honokiol , Analysis standard , 35354-74-6

Synonym(s):
5,3ʹ-Diallyl-2,4ʹ-dihydroxydiphenyl, VEGFR Tyrosine Kinase Inhibitor XIX, VEGFR2 Kinase Inhibitor XV;5,3′-Diallyl-2,4′-dihydroxybiphenyl;Honokiol - CAS 35354-74-6 - Calbiochem;NSC 293100

CAS NO.：35354-74-6

Empirical Formula: C18H18O2

Molecular Weight: 266.33

MDL number: MFCD00016674

EINECS: 609-119-8

PRODUCT Properties

• Melting point: 86℃
• Boiling point: 400.1±40.0 °C(Predicted)
• Density: 1.107±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: 36 mg/mL
• form: powder
• pka: 9.89±0.48(Predicted)
• color: White to Off-White
• Merck: 14,4742
• Stability: Light Sensitive
• InChIKey: FVYXIJYOAGAUQK-UHFFFAOYSA-N
• LogP: 4.200 (est)

Description and Uses

Magnolol is derived from the root bark and branch bark of magnolia or Magnolia officinalis. Magnolia officinalis was first written in the《ben jing》, it prefers cool and humid climate and well-drained acid soil. Cortex magnoliae officinalis (hou po) is mainly produced in Sichuan (Wan quan, Shizhu, Guanxian), Hubei (Shien,Yichang, Lichuan), Zhejiang (Longquan, Anhui), and other places. It is also distributed in Fujian, Jiangxi, Hunan, Guangxi, Yunnan, Guizhou, Shanxi, Gansu, and other places. Cortex magnoliae officinalis from Sichuan and Hubei is called “chuan pu,” with better quality, while in Zhejiang, it is called “warm park,” with a larger output.

Honokiol is a small-molecule polyphenol isolated from the genus Magnolia. Recent studies show that Honokiol displays antiangiogenic, antiinflammatory, and antitumor properties in preclinical models, w ithout appreciable toxicity. Honokiol has been shown to inhibit the bone metastatic growth of human prostate cancer cells.

Safety

• Symbol(GHS): GHS05,GHS09
• Signal word: Danger
• Hazard statements: H318-H411
• Precautionary statements: P273-P280-P305+P351+P338-P391-P501
• Hazard Codes: Xi,N
• Risk Statements: 41-51/53
• Safety Statements: 26-39-61
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• HazardClass: 9
• HS Code: 29072990