Luteolin , ≥98%(HPLC) , 491-70-3

Synonym(s):
3ʹ,4ʹ,5,7-Tetrahydroxyflavone;3′,4′,5,7-Tetrahydroxyflavone;Luteolin - CAS 491-70-3 - Calbiochem

CAS NO.：491-70-3

Empirical Formula: C15H10O6

Molecular Weight: 286.24

MDL number: MFCD00017309

EINECS: 207-741-0

PRODUCT Properties

• Melting point: ~330 °C(lit.)
• Boiling point: 348.61°C (rough estimate)
• Density: 1.2981 (rough estimate)
• refractive index: 1.4413 (estimate)
• storage temp.: 2-8°C
• solubility: Methanol (Slightly, Heated)
• form: powder
• pka: 6.50±0.40(Predicted)
• color: yellow
• Water Solubility: Soluble in aqueous alkaline solutions (1.4 mg/ml), ethanol (~5 mg/ml), dimethyl sulfoxide (7 mg/ml), 1eq. Sodium hydroxide (5 mM), dimethylformamide (~20 mg/ml), water (1 mg/ml) at 25°C and methanol.
• Merck: 14,5614
• BRN: 292084
• InChIKey: IQPNAANSBPBGFQ-UHFFFAOYSA-N
• LogP: 2.40
• CAS DataBase Reference: 491-70-3(CAS DataBase Reference)
• EPA Substance Registry System: Luteolin (491-70-3)

Description and Uses

Luteolin is a flavone derived from Honeysuckle(Lonicera japonica Thunb). Luteolin is widely distributed in nature. It can be isolated from a variety of natural herbs, vegetables, and fruits. At present, luteolin is found mainly in honeysuckle, chrysanthemum, Schizonepeta, Ajuga, artichokes, Scutellaria, and Callicarpa nudiflora natural herbs. Dietary sources include celery, broccoli, green pepper, parsley, thyme, dandelion, perilla, chamomile tea, carrots, olive oil, peppermint, rosemary, navel oranges, and oregano. It can also be found in the seeds of the palm Aiphanes aculeata.

Luteolin has been used:

• to induce and elucidate the apoptotic pathway in renal cell carcinoma 786-O cells
• as an additive in M9 minimal medium to induce nodF gene expression
• as a reference standard to qualitatively and quantitatively analyse luteolin using reverse phase-high performance liquid chromatography with diode array detector (RP-HPLC-DAD)
• as a reaction supplement for β-galactosidase assay
• to elucidate the anti-inflammatory efficacy of luteolin in pseudorabies virus infected RAW264.7 cell line by measuring the anti-inflammatory mediators production and also cell viability and cytotoxicity assay

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36-36/37/39
• WGK Germany: 3
• RTECS: LK9275210
• HS Code: 29329990