Cynaroside , 10mMinDMSO , 5373-11-5
Synonym(s):
Cynaroside;Luteoloside;Glucoluteolin;Glucosylluteolin;Luteolin 7-O-β-D -glucoside
CAS NO.：5373-11-5
Empirical Formula: C21H20O11
Molecular Weight: 448.38
MDL number: MFCD06799436
EINECS: 226-365-8
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB571.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 256～258℃ |
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| Boiling point: | 838.1±65.0 °C(Predicted) |
| Density | 1.713±0.06 g/cm3(Predicted) |
| pka | 6.10±0.40(Predicted) |
| form | Solid |
| color | Yellow to Very Dark Yellow |
| Stability: | Hygroscopic |
| InChIKey | PEFNSGRTCBGNAN-QNDFHXLGSA-N |
| SMILES | C1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)=C2)C(=O)C=1 |&1:17,18,20,22,24,r| |
| LogP | -0.090 (est) |
Description and Uses
Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .
Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.
