Home Categories Biochemical Engineering Cynaroside
A2340612

Cynaroside , ≥98.0%(HPLC) , 5373-11-5

Synonym(s):
Cynaroside;Luteoloside;Glucoluteolin;Glucosylluteolin;Luteolin 7-O-β-D-glucoside

CAS NO.:5373-11-5

Empirical Formula: C21H20O11

Molecular Weight: 448.38

MDL number: MFCD06799436

EINECS: 226-365-8

Pack Size Price Stock Quantity
25MG RMB615.20 In Stock
100MG RMB2135.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 256~258℃
storage temp.  Sealed in dry,2-8°C
solubility  DMSO (Slightly), Methanol (Slightly)
Boiling point: 838.1±65.0 °C(Predicted)
Density  1.713±0.06 g/cm3(Predicted)
pka 6.10±0.40(Predicted)
form  Solid
color  Yellow to Very Dark Yellow
Stability: Hygroscopic
InChIKey PEFNSGRTCBGNAN-QNDFHXLGSA-N
SMILES C1(C2=CC=C(O)C(O)=C2)OC2=C(C(O)=CC(O[C@H]3[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O3)=C2)C(=O)C=1 |&1:17,18,20,22,24,r|
LogP -0.090 (est)

Description and Uses

Luteolin-7-O-glucoside is a flavonoid that has been found in many Chinese herbs with diverse biological activities. It reduces lactate dehydrogenase (LDH) and caspase-3 activities and production of reactive oxygen species (ROS) and increases cell viability and 14-3-3η protein levels in H9C2 cardiomyocytes after anoxia/reoxygenation injury. Luteoloside blocks 3C protease activity (IC50 = 0.36 mM) and reduces the cytopathic effect of enterovirus 71 in rhabdomyosarcoma cells (EC50 = 0.43 mM). It inhibits the growth of hepatocellular carcinoma (HCC) cells in vitro via reduction in ROS accumulation, caspase-1 activity, and expression of the NLRP3 inflammasome and reduces the number of lung metastases in an SMMC-7721 HCC mouse xenograft model when administered at a dose of 2 mg/kg. Luteoloside also reduces acanthosis and expression of epidermal differentiation markers in a mouse model of psoriasis induced by imiquimod .

Luteolin 7-Glucoside is a strong antioxidant ant radical scavenger. Used in cancer prevention.

Safety

Hazard Codes  Xi
Safety Statements  24/25
WGK Germany  3
RTECS  DJ3009400
HS Code  29389090

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