Home Categories 5-Fluoro-2′-deoxycytidine
A7690458

5-Fluoro-2′-deoxycytidine , 10mMinDMSO , 10356-76-0

Synonym(s):
2′-deoxy-5-fluoro-Cytidine;FCDR;FdCyd

CAS NO.:10356-76-0

Empirical Formula: C9H12FN3O4

Molecular Weight: 245.21

MDL number: MFCD00077348

Pack Size Price Stock Quantity
1ml RMB159.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 196 °C
Boiling point: 465℃
Density  1.82
refractive index  70 ° (C=1, H2O)
Flash point: 235℃
storage temp.  Keep in dark place,Inert atmosphere,2-8°C
solubility  DMSO: >20mg/mL
form  powder
pka 14.03±0.60(Predicted)
color  white to off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
CAS DataBase Reference 10356-76-0(CAS DataBase Reference)
EPA Substance Registry System 5-Fluoro-2'-deoxycytidine (10356-76-0)

Description and Uses

5-Fluoro-2-Deoxycytidine is an antimetabolite consisting of a fluorinated pyrimidine analog with potential antineoplastic activity. As a prodrug, 5-fluoro-2-deoxycytidine is converted by intracellular deaminases to the cytotoxic agent 5-Fluorouracil (5-FU). 5-FU is subsequently metabolized to active metabolites including 5-fluoro-2-deoxyuridine monophosphate (FdUMP) and 5-fluorouridine triphosphate (FUTP). FdUMP binds to and inhibits thymidylate synthase, thereby reducing the production of thymidine monophosphate, which leads to depletion of thymidine triphosphate. This inhibits DNA synthesis and cell division. FUTP competes with uridine triphosphate for incorporation into the RNA strand thus leading to an inhibition of RNA and protein synthesis. Other fluorouracil metabolites also get incorporated into both DNA and RNA, thereby further hampering cellular growth.

5-Fluoro-2''-deoxycytidine is a mechanism-based DNMT inhibitor.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H332-H335
Precautionary statements  P261-P280-P305+P351+P338
Hazard Codes  Xn
Risk Statements  22
WGK Germany  3
RTECS  HA3850000
HS Code  2940.00.6000

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