2′-Fluoro-2′-deoxycytidine , >98.0%(T) , 10212-20-1
CAS NO.:10212-20-1
Empirical Formula: C9H12FN3O4
Molecular Weight: 245.21
MDL number: MFCD00057445
EINECS: 1806241-263-5
Pack Size | Price | Stock | Quantity |
1G | RMB190.40 | In Stock |
|
5G | RMB719.20 | In Stock |
|
others | Enquire |
PRODUCT Properties
Melting point: | 167 °C |
Boiling point: | 500.1±60.0 °C(Predicted) |
Density | 1.82±0.1 g/cm3(Predicted) |
refractive index | 80 ° (C=1, MeOH) |
storage temp. | Keep in dark place,Sealed in dry,2-8°C |
solubility | Soluble in DMSO, Methanol. |
pka | 12.84±0.70(Predicted) |
form | Powder |
color | White to Off-white |
Water Solubility | Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C) |
InChI | InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1 |
InChIKey | NVZFZMCNALTPBY-XVFCMESISA-N |
SMILES | OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O |
CAS DataBase Reference | 10212-20-1(CAS DataBase Reference) |
Description and Uses
2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.
2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.
Safety
Symbol(GHS) | GHS07 |
Signal word | Warning |
Hazard statements | H315-H319-H335 |
Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a |
Hazard Codes | Xi |
Risk Statements | 36/37/38 |
Safety Statements | 26-36 |
HS Code | 29389090 |