2′-Fluoro-2′-deoxycytidine , >98.0%(T) , 10212-20-1

CAS NO.：10212-20-1

Empirical Formula: C9H12FN3O4

Molecular Weight: 245.21

MDL number: MFCD00057445

EINECS: 1806241-263-5

PRODUCT Properties

• Melting point: 167 °C
• Boiling point: 500.1±60.0 °C(Predicted)
• Density: 1.82±0.1 g/cm3(Predicted)
• refractive index: 80 ° (C=1, MeOH)
• storage temp.: Keep in dark place,Sealed in dry,2-8°C
• solubility: Soluble in DMSO, Methanol.
• pka: 12.84±0.70(Predicted)
• form: Powder
• color: White to Off-white
• Water Solubility: Water: 5 mg/mL (20.39 mM; ultrasonic and warming and heat to 60°C)
• InChI: InChI=1S/C9H12FN3O4/c10-6-7(15)4(3-14)17-8(6)13-2-1-5(11)12-9(13)16/h1-2,4,6-8,14-15H,3H2,(H2,11,12,16)/t4-,6-,7-,8-/m1/s1
• InChIKey: NVZFZMCNALTPBY-XVFCMESISA-N
• SMILES: OC[C@H]1O[C@@H](N2C=CC(N)=NC2=O)[C@H](F)[C@@H]1O

Description and Uses

2'-Deoxy-2'-fluorocytidine is a nucleoside analog. It has antiviral effects and can synergize with T705 to effectively inhibit Crimean-Congo hemorrhagic fever virus (CCHFV) replication. 2'-Deoxy-2'-fluorocytidine can also inhibit dihydrofolate reductase, thereby preventing the production of tetrahydrofolate, which is required for the synthesis of purines and pyrimidines. It has a certain inhibitory effect on poliovirus, herpes simplex virus, vesicular stomatitis virus and influenza A virus.

2'-Deoxy-2'-fluorocytidine is a potent inhibitor of the subgenomic hepatitis C virus replicon in Huh-7 cells. 2'-Deoxy-2'-fluorocytidine has been shown to inhibit Borna Disease virus replication and s pread.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26-36
• HS Code: 29389090