Home Categories Biochemical Engineering (-)-Epicatechin
A7686258

(-)-Epicatechin , 10mMinDMSO , 490-46-0

Synonym(s):
(−)-cis-3,3′,4′,5,7-Pentahydroxyflavane;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol

CAS NO.:490-46-0

Empirical Formula: C15H14O6

Molecular Weight: 290.27

MDL number: MFCD00075648

EINECS: 207-710-1

Pack Size Price Stock Quantity
1ml RMB239.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 240 °C (dec.)(lit.)
alpha  -55~-65゜(D/20℃)(c=1,CH3OH)
Boiling point: 629.2 °C
Density  1.593±0.06 g/cm3(Predicted)
storage temp.  -20°C
solubility  insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO
form  Solid
pka 9.54±0.10(Predicted)
color  White to Light yellow to Light orange
Water Solubility  Soluble in water or alcohol
Merck  13,1912
BRN  92760
Stability: Hygroscopic
InChIKey PFTAWBLQPZVEMU-UKRRQHHQSA-N
LogP 0.490 (est)

Description and Uses

(−)-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities. It scavenges DPPH radicals in a cell-free assay when used at a concentration of 5 μM. (−)-Epicatechin inhibits COX-1 (IC50 = 3.2 μM). It acts synergistically with epigallocatechin gallate to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 μM. (−)-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation.

An antioxidant and natural product from green tea

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  26-36
WGK Germany  3
RTECS  KB3745000
10-23
HS Code  29329990

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