(-)-Epicatechin , Analysis of standard products, ≥98.0%(HPLC) , 490-46-0
Synonym(s):
(−)-cis-3,3′,4′,5,7-Pentahydroxyflavane;(2R,3R)-2-(3,4-Dihydroxyphenyl)-3,4-dihydro-1(2H)-benzopyran-3,5,7-triol
CAS NO.：490-46-0
Empirical Formula: C15H14O6
Molecular Weight: 290.27
MDL number: MFCD00075648
EINECS: 207-710-1
| Pack Size | Price | Stock | Quantity |
| 20MG | RMB216.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 240 °C (dec.)(lit.) |
| alpha | -55～-65゜(D/20℃)(c=1,CH3OH) |
| Boiling point: | 629.2 °C |
| Density | 1.593±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | insoluble in H2O; insoluble in EtOH; ≥14.5 mg/mL in DMSO |
| form | Solid |
| pka | 9.54±0.10(Predicted) |
| color | White to Light yellow to Light orange |
| Water Solubility | Soluble in water or alcohol |
| Merck | 13,1912 |
| BRN | 92760 |
| Stability: | Hygroscopic |
| InChIKey | PFTAWBLQPZVEMU-UKRRQHHQSA-N |
| LogP | 0.490 (est) |
| CAS DataBase Reference | 490-46-0(CAS DataBase Reference) |
Description and Uses
(−)-Epicatechin is a polyketide synthase-derived polyphenol flavonoid that has been found in T. cacao and has diverse biological activities. It scavenges DPPH radicals in a cell-free assay when used at a concentration of 5 μM. (−)-Epicatechin inhibits COX-1 (IC50 = 3.2 μM). It acts synergistically with epigallocatechin gallate to induce apoptosis in, and reduce the proliferation of, PC-9 lung cancer cells when used at a concentration of 200 μM. (−)-Epicatechin (80 mg/kg) reduces LPS-induced increases in plasma creatinine and urea levels in a rat model of renal inflammation.
An antioxidant and natural product from green tea
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P264-P271-P280-P302+P352-P305+P351+P338 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26-36 |
| WGK Germany | 3 |
| RTECS | KB3745000 |
| F | 10-23 |
| HS Code | 29329990 |
