D-α-Tocopherol Succinate , Analysis standard , 4345-03-3
Synonym(s):
D -α-Tocopherol succinate;Vitamin E succinate
CAS NO.：4345-03-3
Empirical Formula: C33H54O5
Molecular Weight: 530.78
MDL number: MFCD00072055
EINECS: 224-403-8
| Pack Size | Price | Stock | Quantity |
| 100MG | RMB191.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | ~76 °C(lit.) |
| Boiling point: | 625.8±55.0 °C(Predicted) |
| Density | 1.002±0.06 g/cm3(Predicted) |
| vapor pressure | 0Pa at 20℃ |
| storage temp. | -20°C |
| solubility | Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol. |
| form | Solid |
| pka | 4.35±0.17(Predicted) |
| color | White or off-white |
| Odor | Little or no odor |
| λmax | 286nm(EtOH)(lit.) |
| Merck | 14,9495 |
| BRN | 4038233 |
| Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month. |
| LogP | 12 at 25℃ |
| CAS DataBase Reference | 4345-03-3(CAS DataBase Reference) |
| EPA Substance Registry System | D-.alpha.-Tocopheryl acid succinate (4345-03-3) |
Description and Uses
Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2?Tocopherol succinate induces apoptosis in human gastric cancer cells3?and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5
A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P301+P312-P302+P352-P304+P340-P305+P351+P338 |
| WGK Germany | 1 |
| RTECS | EJ9984000 |
| F | 8-10-23 |
| HS Code | 2936280000 |
| Toxicity | LD50 oral in rat: > 7gm/kg |
