D-α-Tocopherol Succinate , 98% , 4345-03-3

Synonym(s):
D-α-Tocopherol succinate;Vitamin E succinate

CAS NO.：4345-03-3

Empirical Formula: C33H54O5

Molecular Weight: 530.78

MDL number: MFCD00072055

EINECS: 224-403-8

PRODUCT Properties

• Melting point: ~76 °C(lit.)
• Boiling point: 625.8±55.0 °C(Predicted)
• Density: 1.002±0.06 g/cm3(Predicted)
• vapor pressure: 0Pa at 20℃
• storage temp.: -20°C
• solubility: Practically insoluble in water, very soluble in methylene chloride, soluble in acetone and in anhydrous ethanol.
• form: Solid
• pka: 4.35±0.17(Predicted)
• color: White or off-white
• Odor: Little or no odor
• λmax: 286nm(EtOH)(lit.)
• Merck: 14,9495
• BRN: 4038233
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
• LogP: 12 at 25℃
• CAS DataBase Reference: 4345-03-3(CAS DataBase Reference)
• EPA Substance Registry System: D-.alpha.-Tocopheryl acid succinate (4345-03-3)

Description and Uses

Tocopherol succinate (4345-03-3) is a potent antioxidant. Protects mice from gamma-radiation by induction of granulocyte-colony stimulating factor.1,2?Tocopherol succinate induces apoptosis in human gastric cancer cells3?and inhibits proliferation of mesothelioma cells by down-regulation of fibroblast growth factor receptor-14. Induces apoptosis in neuroblastoma cells.5

A potent novel antineoplastic agent with high selectivity and cooperativity with tumor necrosis factor-related apoptosis-inducing ligand (Apo2 ligand). It inhibits proliferation of mesothelioma cells by selective down-regulation of fibroblast growth factor receptors. Furthermore, it has been shown to enhance the anti-tumor effect of dendritic cell vaccines.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P261-P301+P312-P302+P352-P304+P340-P305+P351+P338
• WGK Germany: 1
• RTECS: EJ9984000
• F: 8-10-23
• HS Code: 2936280000
• Toxicity: LD50 oral in rat: > 7gm/kg