2-Thenoyltrifluoroacetone , 98% , 326-91-0
Synonym(s):
4,4,4-Trifluoro-1-(2-thienyl)-1,3-butanedione;TTA (extractant);TTB;TTFA
CAS NO.：326-91-0
Empirical Formula: C8H5F3O2S
Molecular Weight: 222.18
MDL number: MFCD00005445
EINECS: 206-316-7
| Pack Size | Price | Stock | Quantity |
| 5G | RMB24.00 | In Stock |
|
| 25G | RMB67.20 | In Stock |
|
| 100G | RMB225.60 | In Stock |
|
| 500G | RMB863.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 40-44 °C(lit.) |
| Boiling point: | 96-98 °C8 mm Hg(lit.) |
| Density | 1.4373 (estimate) |
| Flash point: | 233 °F |
| storage temp. | 2-8°C |
| solubility | sparingly soluble in water, readily soluble in organic solvents. Distribution ratio between acidic water and benzene is about 40. In alkaline aqueous medium it exists in the enolate form, this being relatively more soluble in water. The equilibrium distribution ratio between benzene and alkaline aqueous medium (about pH 8) is about 1. In alkaline aqueous medium of pH > 9 TTA decomposes to trifluoroacetone and acetylthiophen. |
| pka | 5.60±0.23(Predicted) |
| form | Crystalline Powder, Crystals and/or Chunks |
| color | Light yellow or beige to brown |
| Odor | Odorless |
| Water Solubility | INSOLUBLE |
| BRN | 168645 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| InChIKey | TXBBUSUXYMIVOS-UHFFFAOYSA-N |
| CAS DataBase Reference | 326-91-0(CAS DataBase Reference) |
| NIST Chemistry Reference | 1,3-Butanedione, 4,4,4-trifluoro-1-(2-thienyl)-(326-91-0) |
| EPA Substance Registry System | 1,3-Butanedione, 4,4,4-trifluoro-1-(2-thienyl)- (326-91-0) |
Description and Uses
TTFA?(326-91-0) blocks the respiratory chain complex II causing inhibition of mitochondrial respiration.? Respiratory chain complex II inhibition is caused via binding of TTFA to two ubiquinone binding sites, Qp and Qd.1?Inhibition of Complex II by TFA has been shown to cause a delay in overall cell cycle progression leading to oxidative stress.2,3?TTFA also was found to inhibit porcine liver carboxylesterase (IC50?= 0.54 μM).4
Thenoyltrifluoroacetone is one of the most proved extracting agents in solventextraction analysis. It is equally suitable for the separation and selective enrichment of metal ions.
2-Thenoyltrifluoroacetone (TTFA) is an inhibitor of respiration in animals and bacteria. In animals, TTFA binds at the quinone reduction site of succinate:ubiquinone oxidoreductase (SQR; Complex II), preventing ubiquinone from binding. It inhibits NADH fumarate reductase in bacteria. TTFA also inhibits photosystem II in plants and NADH-ubiquinone oxidoreductase of the virus Vibrio cholerae, decreasing cholera toxin production. This compound is also a chelator of metals, including lanthanum, zirconium, hafnium, and neodymium. Reagent for the determination of actinides and lanthanides.
2-Thenoyltrifluoroacetone is used for the extractive spectrophotometric determination of ruthenium at ph 4.0 (acetate buffer).
Thenoyltrifluoroacetone has also been used as an alternative β-diketone for in-house assay development since NTA was not, until recently, commercially available.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P280g-P305+P351+P338 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-22 |
| Safety Statements | 26-36-37/39 |
| WGK Germany | 3 |
| F | 10-23 |
| TSCA | T |
| HazardClass | IRRITANT |
| HS Code | 29349990 |
