Terbutaline hemisulfate salt , Analysis standard , 23031-32-5

Synonym(s):
2-t-Butylamino-1-(3,5-dihydroxyphenyl)ethanol;5-[2-[(1,1-Dimethylethyl)amino]-1-hydroxyethyl]-1,3-benzenediol hemisulfate salt;Terbutaline hemisulfate salt

CAS NO.：23031-32-5

Empirical Formula: C24H40N2O10S

Molecular Weight: 548.65

MDL number: MFCD00079584

EINECS: 245-386-3

PRODUCT Properties

• Melting point: 246-248°C
• Density: 1.1840 (rough estimate)
• refractive index: 1.6900 (estimate)
• storage temp.: 2-8°C
• solubility: H2O: soluble100mg/mL, clear to slightly hazy, colorless to yellow
• pka: pKa1 8.8, pKa2 10.1, pKa3 11.2(at 25℃)
• form: Solid
• color: White to Off-White
• InChI: InChI=1S/2C12H19NO3.H2O4S/c2*1-12(2,3)13-7-11(16)8-4-9(14)6-10(15)5-8;1-5(2,3)4/h2*4-6,11,13-16H,7H2,1-3H3;(H2,1,2,3,4)
• InChIKey: KFVSLSTULZVNPG-UHFFFAOYSA-N
• SMILES: C1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.C1(=CC(=CC(O)=C1)O)C(O)CNC(C)(C)C.S(=O)(=O)(O)O

Description and Uses

Terbutaline is the N-t-butyl analogue of metaproterenol and, as such, would be expected to have a more potent β2-selectivity. When compared to metaproterenol, terbutaline has a threefold greater potency at the β2-receptor. Like metaproterenol, it is resistant to COMT and slowly metabolized by MAO, therefore having good oral bioavailability with similar onset and duration. Terbutaline is available as tablets and solutions for injection and inhalation. Adverse effects are similar to other direct-acting β2-selective agonists, however, with a greater incidence of palp

Anti Asthmatic

Safety

• Symbol(GHS): GHS08
• Signal word: Warning
• Hazard statements: H361
• Precautionary statements: P280
• Hazard Codes: Xn
• Risk Statements: 42/43-63
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: DN9000000
• HS Code: 2922504500
• Toxicity: dog,LD50,intravenous,116mg/kg (116mg/kg),Kiso to Rinsho. Clinical Report. Vol. 6, Pg. 757, 1972.