MK571sodiumsalt(L660711sodiumsalt) , 10mMinDMSO , 115104-28-4

CAS NO.：115104-28-4

Empirical Formula: C26H27ClN2O3S2

Molecular Weight: 515.09

MDL number: MFCD00878420

PRODUCT Properties

• Melting point: 65-70°C
• Boiling point: 712.3±60.0 °C(Predicted)
• Density: 1.327±0.06 g/cm3(Predicted)
• storage temp.: Store at -20°C
• solubility: Soluble in DMSO (up to 50 mg/ml).
• pka: 4.27±0.10(Predicted)
• form: Off-white solid.
• color: Yellow
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.

Description and Uses

MK-571 is a selective, orally active CysLT₁ receptor antagonist. It blocks the binding of LTD₄, but not LTC₄, to human and guinea pig lung membranes with K_i values of 0.22 nM and 2.1 nM, respectively, which is indicative of CysLT₁ receptor-mediated activity in these preparations. MK-571 effectively blocks LTD₄ activation of recombinant human and murine CysLT₁ receptors but is ineffective at blocking LTC₄ or LTD₄ activation of the recombinant human or murine CysLT₂ receptors.

A receptor antagonist for the treatment of respiratory diseases. Cysteinyl leukotriene receptor antagonist MK-571 alters bronchoalveolar lavage fluid proteome in asthma.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P321-P362+P364-P332+P313-P337+P313-P403+P233-P405-P501