Omarigliptin(MK-3102) , 10mMinDMSO , 1226781-44-7
CAS NO.：1226781-44-7
Empirical Formula: C17H20F2N4O3S
Molecular Weight: 398.43
MDL number: MFCD22573261
EINECS: 682-558-0
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB159.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Boiling point: | 529.4±60.0 °C(Predicted) |
| Density | 1.61±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C(protect from light) |
| solubility | insoluble in EtOH; insoluble in H2O; ≥17.15 mg/mL in DMSO |
| form | solid |
| pka | 9.11±0.60(Predicted) |
| color | White to off-white |
| InChI | InChI=1S/C17H20F2N4O3S/c1-27(24,25)23-7-10-6-22(8-16(10)21-23)12-5-15(20)17(26-9-12)13-4-11(18)2-3-14(13)19/h2-4,7,12,15,17H,5-6,8-9,20H2,1H3/t12-,15+,17-/m1/s1 |
| InChIKey | MKMPWKUAHLTIBJ-ISTRZQFTSA-N |
| SMILES | [C@H]1(C2=CC(F)=CC=C2F)OC[C@H](N2CC3=CN(S(C)(=O)=O)N=C3C2)C[C@@H]1N |
Description and Uses
Merck earned its first global approval for omarigliptin in Japan in 2015, and phase III development is ongoing in other countries around the globe for this interesting small molecule DPP-4 inhibitor. Interestingly, while most DPP-4 inhibitors used to treat type 2 DM require daily administration, omarigliptin is a weekly treatment. The process-scale synthesis of omarigliptin has been nicely described in an October 2015 paper from the Merck process group.
Omarigliptin is a potent and selective dipeptidyl peptidase 4 (DPP-4) inhibitor to be used as treatment for type 2 diabetes.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
