E-64 , 10mMinDMSO , 66701-25-5
Synonym(s):
E-64;N-(trans-Epoxysuccinyl)-L -leucine 4-guanidinobutylamide;n-[n-( l-transepoxysuccinic acid)-l-leucyl]-agmatine;n-[n-(l-3-trans-carboxirane-2-carbonyl)-l-leucyl]-4-aminobutylguanidine;L -trans-3-Carboxyoxiran-2-carbonyl-L -leucylagmatine
CAS NO.：66701-25-5
Empirical Formula: C15H27N5O5
Molecular Weight: 357.41
MDL number: MFCD07366493
EINECS: 613-978-4
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB559.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | >170°C (dec.) |
| Density | 1.44±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | H2O: 20 mg/mL, clear, colorless |
| pka | 3.16±0.40(Predicted) |
| form | White solid |
| color | White or off-white |
| Water Solubility | Soluble in DMSO (25mg/ml), or water (20mg/ml) |
| Sensitive | Light Sensitive |
| BRN | 1405664 |
| Stability: | Stable for 1 year from date of purchase as supplied. |
| InChIKey | LTLYEAJONXGNFG-DCAQKATOSA-N |
| SMILES | O1[C@H](C(N[C@H](C(NCCCCNC(N)=N)=O)CC(C)C)=O)[C@H]1C(O)=O |
| CAS DataBase Reference | 66701-25-5(CAS DataBase Reference) |
Description and Uses
E-64 (66701-25-5) is a cell-permeable, epoxysuccinyl peptide irreversible inhibitor of calpain and other cysteine proteases.1,2?Inhibits calpain-dependent apoptosis pathway in T cells3?but promotes heat-induced apoptosis in FM3A cells. Typical working concentration is 0.5-10 μg/ml.4
It is used as a broad spectrum cysteine proteinase and calpain activation inhibitor. Additionally, Prevotella intermediate studies report that E-64 blocks the breakdown of methaemoglobin and the oxidation of oxyhaemoglobin by InpA. E-64 has also been used to study excystation in Giardia lamblia. E-64 is an inhibitor of Calpain, cathepsin K and cathepsin S. E-64 is an effective ligand for affinity purification of cysteine proteases. When coupled to a thiolated affinity matrix, binding is no longer irreversible, but specificity is retained
Safety
| Symbol(GHS) |  GHS08 |
| Signal word | Warning |
| Hazard statements | H371 |
| Precautionary statements | P260-P264-P270-P308+P311-P405-P501 |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| RTECS | RR0390000 |
| F | 10 |
| HS Code | 29252900 |
