Leupeptin , 10mMinDMSO , 103476-89-7
Synonym(s):
Leupeptin hemisulfate;Leupeptin hemisulfate salt;N-Acetyl-L -leucyl-L -leucyl-L -argininal hemisulfate salt;N-Acetyl-L -leucyl-L -leucyl-L -argininal;Acetyl-L -leucyl-L -leucylargininal
CAS NO.：103476-89-7
Empirical Formula: C20H38N6O4
Molecular Weight: 426.55
MDL number: MFCD00081028
EINECS: 600-443-5
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB639.20 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| alpha | -76 º (c=1, water) |
| storage temp. | -20°C |
| solubility | H2O: 10 mM Solutions are stable for a week at 4 °C. Stock solutions are stable up to 6 months at −20°C. |
| form | Powder |
| color | White to Off-white |
| Water Solubility | soluble |
| Stability: | Stable for 1 year from date of purchase as supplied Solutions in distilled water, ethanol or methanol may be stored at -20°C for up to 3 months. |
| InChIKey | CIPMKIHUGVGQTG-VFFZMTJFSA-N |
Description and Uses
Leupeptin hemisulfate (103476-89-7) is a reversible inhibitor of trypsin-like proteases and cysteine proteases. Inhibits trypsin, plasmin, papain and cathepsin B, H and L.1-3?Blocks various apoptotic pathways in T cells.4?Commonly used in cell lysis buffers to protect proteins from degradation. Typical working concentration is 1μM (0.5 μg/ml).
Leupeptin has been used as a protease inhibitor: in ice-cold lysis buffer to harvest cells for western immunoblotting and immunoprecipitation,in chromatin immunoprecipitation (ChIP) lysis buffer for the isolation of fragmented chromatin samples in lysis buffer I to lyse the cells for tandem affinity purification (TAP)
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H302+H312+H332 |
| Precautionary statements | P261-P264-P280-P302+P352+P312-P304+P340+P312-P501 |
| Hazard Codes | Xn |
| Risk Statements | 20/21/22-63-36/37/38 |
| Safety Statements | 22-24/25-36/37-36-36/37/39-26-7/8 |
| RIDADR | 3077 |
| WGK Germany | 3 |
| F | 10-23 |
| HS Code | 29252900 |
