SB525334 , ≥98% , 356559-20-1

Synonym(s):
6-[2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl]-quinoxaline;ALK5 Inhibitor VIII, SB-525334, 6-(2-tert-Butyl-5-(6-methyl-pyridin-2-yl)-1H-imidazol-4-yl)-quinoxaline, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor VIII;TGF-β RI Kinase Inhibitor VIII - CAS 356559-20-1 - Calbiochem

CAS NO.：356559-20-1

Empirical Formula: C21H21N5

Molecular Weight: 343.42

MDL number: MFCD11045307

PRODUCT Properties

• Melting point: 159 °C
• Boiling point: 540.5±45.0 °C(Predicted)
• Density: 1.191
• storage temp.: 2-8°C
• solubility: DMSO: ≥20mg/mL
• pka: 10.24±0.10(Predicted)
• form: Yellow solid
• color: yellow
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: DKPQHFZUICCZHF-UHFFFAOYSA-N

Description and Uses

SB-525334 is a potent inhibitor of the TGF-β receptor 1 (TGF-β R1, ALK5) kinase (IC₅₀ = 14.36 nM). It is ~4-fold less effective against ALK4 and inactive against ALK2, ALK3, and ALK6. SB-525334 blocks TGF-β1-induced phosphorylation and nuclear translocation of SMAD2/3 as well as TGF-β1-directed gene expression. It is effective in vivo, preventing puromycin aminonucleoside-induced renal fibrosis and bleomycin-induced pulmonary fibrosis. SB-525334 also modulates carcinogenesis and suppresses the development of pulmonary arterial hypertension in animals.

SB-525334 is a potent activin receptor-like kinase (ALK5)/ type I TGFβ-receptor kinase inhibitor with IC50 = 14.3 nM.

Safety

• Symbol(GHS): GHS06
• Signal word: Danger
• Hazard statements: H301-H315-H319-H335-H413
• Precautionary statements: P261-P301+P310-P305+P351+P338
• Hazard Codes: Xn
• Risk Statements: 22-36/37/38
• Safety Statements: 26
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• HS Code: 2933.39.6190