Home Categories Biochemical Engineering GW788388
A4645412

GW788388 , ≥98% , 452342-67-5

CAS NO.:452342-67-5

Empirical Formula: C25H23N5O2

Molecular Weight: 425.48

MDL number: MFCD16038936

Pack Size Price Stock Quantity
5MG RMB388.80 In Stock
10MG RMB486.40 In Stock
50MG RMB1969.60 In Stock
250MG RMB5599.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Density  1.34
storage temp.  2-8°C
solubility  Soluble in DMSO (18 mg/ml with warming)
form  solid
color  Off-white
Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Description and Uses

GW 788388 is a selective inhibitor of transforming growth factor-β (TGF-β) type 1 receptor (TGFBR1 or ALK5; IC50 = 18 nM). It inhibits the expression of collagen type I in cells (IC50 = 93 nM) and in mice when given orally at 10 mg/kg once a day. As TGF-β stimulates fibrosis in a range of tissues, GW 788388 reduces typical features of fibrosis, including tissue remodeling, increased expression of α-smooth muscle actin and production of collagen I. GW 788388 also blocks TGF-β-mediated production of VEGF by fibroblasts, as well as subsequent angiogenesis in vitro. Inhibition of ALK5 signaling by GW 788388 also induces hypertrophy in femoral growth plates in rats.

GW788388 is a new TGF-beta type I receptor inhibitor with a much improved pharmacokinetic profile compared with SB431542.

Safety

Symbol(GHS) 
GHS07
Signal word  Warning
Hazard statements  H302-H315-H320-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338

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