RepSox , ≥98% , 446859-33-2

Synonym(s):
ALK5 Inhibitor II, Transforming Growth Factor-β Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;E-616452; 2-[3-(6-Methyl-2-pyridinyl)-1H-pyrazol-4-yl]-1,5-naphthyridine;InSolution TGF-β RI Kinase Inhibitor II, RepSox - CAS 446859-33-2 - Calbiochem;RepSox InSolution, E-616452 InSolution, ALK5 Inhibitor II, Transforming Growth Factor-β, Type I Receptor Kinase Inhibitor II, 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine;TGF-β RI Kinase Inhibitor II - CAS 446859-33-2 - Calbiochem

CAS NO.：446859-33-2

Empirical Formula: C17H13N5

Molecular Weight: 287.32

MDL number: MFCD09037561

PRODUCT Properties

• Melting point: 195 °C
• Boiling point: 501.9±50.0 °C(Predicted)
• Density: 1.296±0.06 g/cm3(Predicted)
• storage temp.: 2-8°C
• solubility: DMSO: >20mg/mL
• form: Yellow solid
• pka: 10.05±0.50(Predicted)
• color: Pale yellow
• Stability: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• InChIKey: LBPKYPYHDKKRFS-UHFFFAOYSA-N

Description and Uses

RepSox (446859-33-2) is a potent (IC50?ALK5 auto-P= 4 nM; IC50?TGF-β cellular assay = 23 nM) inhibitor of the TGF-β type I receptor (ALK5).1?RepSox can replace Sox2 in reprogramming adult cells into pluripotent stem cells via induction of Nanog transcription.2?It was able to convert astrocytes into neuronal cells as part of a small molecule cocktail (along with valproic acid and CHIR99021).3,4

Alk 5 Inhibitor II is a selective ATP competitive inhibitor of transforming growth factor-β (TGFβ). A potential drug for the treatment of fibrosis and cancer.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H315-H319-H335
• Precautionary statements: P280-P305+P351+P338
• Hazard Codes: T
• Risk Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811
• WGK Germany: 3