Sulfadoxin , Analysis standard , 2447-57-6
Synonym(s):
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;Sulfadoxin;Sulfadoxine
CAS NO.：2447-57-6
Empirical Formula: C12H14N4O4S
Molecular Weight: 310.33
MDL number: MFCD00792890
EINECS: 219-504-9
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB292.00 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 190-194°C |
| Boiling point: | 298°C (rough estimate) |
| Density | 1.4006 (rough estimate) |
| refractive index | 1.6270 (estimate) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml |
| form | powder |
| pka | 6.16±0.50(Predicted) |
| color | white |
| Water Solubility | 209.8mg/L(temperature not stated) |
| Merck | 14,8906 |
| BRN | 625453 |
| BCS Class | 3/1 |
Description and Uses
Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid synthesis. Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid. Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum. Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC50 = 4 ng/ml) and resistant strains (IC50 = 3,970 ng/ml).
Used as an antibacterial.
Safety
| Symbol(GHS) |   GHS07,GHS09 |
| Signal word | Warning |
| Hazard statements | H317-H411 |
| Precautionary statements | P261-P272-P273-P280-P302+P352-P333+P313 |
| Hazard Codes | Xi |
| Risk Statements | 36/37/38 |
| Safety Statements | 26 |
| WGK Germany | 2 |
| RTECS | DA9500000 |
| HS Code | 29350090 |
| Toxicity | LD50 in mice (microcrystals, mg/kg): 5200 orally, 2900 s.c., 2900 i.p. (Bhni) |
