Sulfamethoxazole , Analysis standard product, 99% , 723-46-6
Synonym(s):
N1-(5-Methylisoxazol-3-yl)sulfanilamide;4-Amino-N-(5-methyl-3-isoxazolyl)benzenesulfonamide
CAS NO.：723-46-6
Empirical Formula: C10H11N3O3S
Molecular Weight: 253.28
MDL number: MFCD00010546
EINECS: 211-963-3
| Pack Size | Price | Stock | Quantity |
| 250MG | RMB230.40 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 166 °C |
| Boiling point: | 482℃ |
| Density | 1.3915 (rough estimate) |
| refractive index | 1.6630 (estimate) |
| Flash point: | >110°(230°F) |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Practically insoluble in water, freely soluble in acetone, sparingly soluble in ethanol (96 per cent). It dissolves in dilute solutions of sodium hydroxide and in dilute acids. |
| pka | pKa 5.60±0.05 (Uncertain) |
| form | Solid |
| color | White to Pale Yellow |
| Water Solubility | Soluble in ethanol or acetone. Very slightly soluble in water |
| Sensitive | Light Sensitive |
| Merck | 14,8918 |
| BRN | 6732984 |
| BCS Class | 2,4 |
| Stability: | Stable, but light sensitive. Incompatible with strong oxidizing agents. |
| InChIKey | JLKIGFTWXXRPMT-UHFFFAOYSA-N |
| CAS DataBase Reference | 723-46-6(CAS DataBase Reference) |
| IARC | 3 (Vol. Sup 7, 79) 2001 |
| NIST Chemistry Reference | Sulfanilamide, n1-(5-methyl-3-isoxazolyl)-(723-46-6) |
| EPA Substance Registry System | Sulfamethoxazole (723-46-6) |
Description and Uses
Like sulfisoxazole, this drug is effective in treating infections caused by streptococci, gonococci, pneumococci, staphylococci as well as colon bacillus. Unlike sulfisoxazole, only about 70% of it binds with proteins in the plasma after oral administration, and it diffuses mostly to tissues and tissue fluids. However, since it is removed much slower than sulfisoxazole, it does not require frequent administration and is also the drug of choice for many systemic infections. Moreover, it is an ingredient of a combined drug named bactrim, biseptol, and so on (which will be examined later on), which has a fixed correlation with trimethoprim. Synonyms of this drug are gantanol, sinomin, sulfisomezole, and others.
An antibacterial drug. Sulfonamide antibiotic that blocks the synthesis of dihydrofolic acid by inhibiting the enzyme dihydropteroate synthase.This compound is a contaminant of emerging concern (CECs).
Safety
| Symbol(GHS) |   GHS07,GHS08 |
| Signal word | Warning |
| Hazard statements | H317-H361d |
| Precautionary statements | P201-P280-P302+P352-P308+P313 |
| Hazard Codes | Xi,Xn |
| Risk Statements | 36/37/38-43-22 |
| Safety Statements | 26-36-36/37/39-22 |
| WGK Germany | 2 |
| RTECS | WP0700000 |
| TSCA | Yes |
| HazardClass | IRRITANT |
| HS Code | 29350090 |
| Hazardous Substances Data | 723-46-6(Hazardous Substances Data) |
| Toxicity | LD50 orally in mice: 3662 mg/kg (Yamamoto) |
