Sulfadoxin , 96% , 2447-57-6

Synonym(s):
4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide;Sulfadoxin;Sulfadoxine

CAS NO.：2447-57-6

Empirical Formula: C12H14N4O4S

Molecular Weight: 310.33

MDL number: MFCD00792890

EINECS: 219-504-9

PRODUCT Properties

• Melting point: 190-194°C
• Boiling point: 298°C (rough estimate)
• Density: 1.4006 (rough estimate)
• refractive index: 1.6270 (estimate)
• storage temp.: Keep in dark place,Inert atmosphere,Room temperature
• solubility: Soluble in ethanol & ammonium hydroxide (9:1) at 20mg/ml
• form: powder
• pka: 6.16±0.50(Predicted)
• color: white
• Water Solubility: 209.8mg/L(temperature not stated)
• Merck: 14,8906
• BRN: 625453
• BCS Class: 3/1

Description and Uses

Sulfadoxin is a sulfonamide antibiotic that inhibits dihydropteroate synthetase (DHPS), an enzyme involved in folic acid synthesis. Sulfadoxin competes with 4-aminobenzoate (PABA), the native substrate of DHPS, and inhibits PABA incorporation into folic acid. Folate is essential for purine and pyrimidine synthesis, therefore, sulfadoxin has antiproliferative activity in non-resistant P. falciparum. Sulfadoxin inhibits growth of P. falciparum in vitro, but potency varies between non-resistant (IC₅₀ = 4 ng/ml) and resistant strains (IC₅₀ = 3,970 ng/ml).

Used as an antibacterial.

Safety

• Symbol(GHS): GHS07,GHS09
• Signal word: Warning
• Hazard statements: H317-H411
• Precautionary statements: P261-P272-P273-P280-P302+P352-P333+P313
• Hazard Codes: Xi
• Risk Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 2
• RTECS: DA9500000
• HS Code: 29350090
• Toxicity: LD50 in mice (microcrystals, mg/kg): 5200 orally, 2900 s.c., 2900 i.p. (Bhni)