Sulfanilamide , Analysis standard , 63-74-1

Synonym(s):
Sulfanilamide;4-Aminobenzenesulfonamide;CHGC;Chromogranin-C;p-Aminobenzenesulfonamide

CAS NO.：63-74-1

Empirical Formula: C6H8N2O2S

Molecular Weight: 172.2

MDL number: MFCD00007939

EINECS: 200-563-4

PRODUCT Properties

• Melting point: 164-166 °C(lit.)
• Boiling point: 400.5±47.0 °C(Predicted)
• Density: 1.08
• vapor pressure: 0.00001 hPa (70 °C)
• refractive index: 1.6490 (estimate)
• storage temp.: 2-8°C
• solubility: 5.37g/l
• pka: pKa 10.65(H2O t = 25.0±0.5 I = 0.2) (Uncertain)
• form: powder
• color: white to faintly beige
• PH: 5.8-6.1 (5g/l, H2O, 20℃)
• Odor: Odorless
• PH Range: 5.8 - 6.1 (0.5% aq.sol.)
• Water Solubility: 7.5 g/L at 25 ºC
• λmax: 257nm(H2O)(lit.)
• Merck: 14,8925
• BRN: 511852
• InChIKey: FDDDEECHVMSUSB-UHFFFAOYSA-N
• LogP: -0.620

Description and Uses

Sulfanilamide is an organic sulfur compound structurally similar to p-aminobenzoic acid (PABA) with antibacterial property. Sulfanilamide competes with PABA for the bacterial enzyme dihydropteroate synthase, thereby preventing the incorporation of PABA into dihydrofolic acid, the immediate precursor of folic acid. This leads to an inhibition of bacterial folic acid synthesis and de novo synthesis of purines and pyrimidines, ultimately resulting in cell growth arrest and cell death.

Sulfanilamide is an antibacterial agent and antimicrobial agent of sulfonamide type (topical and vaginal).

Safety

• Symbol(GHS): GHS07,GHS05
• Signal word: Warning
• Hazard statements: H303-H315-H314-H319-H335
• Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a-P260h-P301+P330+P331-P303+P361+P353
• Hazard Codes: Xn
• Risk Statements: 40
• Safety Statements: 24/25-36-22
• WGK Germany: 3
• RTECS: WO8400000
• F: 10
• TSCA: Yes
• HazardClass: 8
• HS Code: 29350090
• Toxicity: LD50 orally in mice: 3.8 g/kg (Marshall)