Rabeprazole sodium , ≥98.0%(HPLC) , 117976-90-6

Synonym(s):
2-([4-(3-Methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole;Pariprazole;Rabeprazole sodium

CAS NO.：117976-90-6

Empirical Formula: C18H20N3NaO3S

Molecular Weight: 381.42

MDL number: MFCD02092688

EINECS: 629-730-3

PRODUCT Properties

• Melting point: 140-141°C dec.
• storage temp.: -20°C
• solubility: H2O: soluble10mg/mL (clear solution)
• form: powder
• color: white to beige
• Merck: 14,8089
• Stability: Hygroscopic
• InChIKey: KRCQSTCYZUOBHN-UHFFFAOYSA-N

Description and Uses

Rebeprazole sodium was launched as Pariet in Japan, its first market, for the treatment of peptic ulcers including gastric and duodenal ulcers. From 4-chloro- 2,3-dimethylpyridine N-oxide, a six step synthesis allows access to the basic skeleton after successive condensations. Rabeprazole, a structural analog of Omeprazole, the first compound to have been marketed in this class up to now, is reported to be a more potent inhibitor of gastric H+/K+-adenosine triphosphate (ATPase) ; a common mechanism of action of this chemical class involves the conversion at low pH to a reactive sulphonamide that itself binds to cysteine residues located on the enzyme. Moreover, rabeprazole showed an antibacterial activity against Helicobacter Pylori, with a MIC90 of 1.56 μg/ml.
Rebeprazole sodium has a faster onset of action compared with omeprazole, but a shorter duration of action, being extensively and rapidly metabolized in several animal species. In clinical studies in patients with gastric ulcers, 10 and 20 mg rabeprazole sodium once-daily significantly inhibited basal and stimulated acid output. Rabeprazole is awaiting registration in the US for treatment of gastrooesophageal reflux disease (GORD) and other pathologic hypersecretory conditions including Zollinger-Ellison syndrome.

antibacterial and antifungal agent effective against gram-positive and gram-negative bacteria, yeast and fungi

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H302-H413
• Precautionary statements: P264-P270-P273-P301+P312-P501
• WGK Germany: 3
• HS Code: 2933399090