Reserpine , Analysis of standard products, ≥99.5% , 50-55-5

Synonym(s):
(3β, 16β, 17α, 18β, 20α)-11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester;Reserpine;Reserpine - CAS 50-55-5 - Calbiochem;VMAT2 Inhibitor, Reserpine, Vesicular monoamine transporter (VMAT) Antagonist, Reserpine

CAS NO.：50-55-5

Empirical Formula: C33H40N2O9

Molecular Weight: 608.69

MDL number: MFCD00005091

EINECS: 200-047-9

PRODUCT Properties

• Melting point: ~265 °C (dec.)
• alpha: D23 -118° (CHCl3); D26 -164° (c = 0.96 in pyridine); D26 -168° (c = 0.624 in DMF)
• Boiling point: 655.12°C (rough estimate)
• Density: 1.2336 (rough estimate)
• refractive index: 177 ° (C=1, DMF)
• Flash point: 22℃
• storage temp.: Inert atmosphere,Room Temperature
• solubility: Practically insoluble in water, very slightly soluble in ethanol (96 per cent).
• pka: 6.6(at 25℃)
• form: Solid
• color: Off-white
• optical activity: [α]20/D 123±3°, c = 1% in chloroform
• Water Solubility: Soluble in water.
• Merck: 14,8145
• BRN: 102014
• Stability: Stable, but darkens slowly in light. Combustible. Incompatible with strong acids, reducing agents, oxidizing agents.
• InChIKey: QEVHRUUCFGRFIF-MDEJGZGSSA-N
• LogP: 4.050 (est)

Description and Uses

Reserpine causes release of norepinephrine, dopamine, and serotonin at neuronal termini. It weakens the intracellular uptake of biogenic amines and decreases the ability to store them in vesicles.

An indole alkaloid found in Rauwolfia serpentina. Inhibits vesicular uptake of catecholamines and serotonin. Reserpine is reasonably anticipated to be a human carcinogen. Antihypertensive.

Safety

• Symbol(GHS): GHS07,GHS08
• Signal word: Danger
• Hazard statements: H302-H336-H351-H360D
• Precautionary statements: P201-P301+P312+P330-P308+P313
• Hazard Codes: Xn,Xi
• Risk Statements: 22-67-36-10
• Safety Statements: 22-36/37/39-26
• RIDADR: 3077
• WGK Germany: 3
• RTECS: ZG0350000
• F: 10-23
• TSCA: Yes
• PackingGroup: II
• HS Code: 29399990
• Toxicity: LD50 oral in rat: 420mg/kg