Triptolide , 98% , 38748-32-2
Synonym(s):
PG 490;PG490;Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem
CAS NO.：38748-32-2
Empirical Formula: C20H24O6
Molecular Weight: 360.4
MDL number: MFCD00210565
EINECS: 683-214-2
| Pack Size | Price | Stock | Quantity |
| 50MG | RMB2876.80 | In Stock |
|
| others | Enquire |
PRODUCT Properties
| Melting point: | 226-227°C |
| alpha | D25 -154° |
| Boiling point: | 412.43°C (rough estimate) |
| Density | 1.1656 (rough estimate) |
| refractive index | 1.4450 (estimate) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble |
| form | solid |
| pka | 14.25±0.60(Predicted) |
| color | white to off-white |
| Merck | 14,9747 |
| Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| InChIKey | DFBIRQPKNDILPW-CIVMWXNOSA-N |
Description and Uses
Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity.? Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1??Blocks transactivation of NFkB.2?Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50?= 12 nM) and synergizes with other anticancer agents.3?Inhibits the inflammatory response and remarkably decreases production of TNF-a, IL-1b and IL-6 in a rat model of rheumatoid arthritis.4
Triptolide is a diterpenoid triepoxide with immunosuppressant and antitumor properties.
Safety
| Symbol(GHS) |   GHS06,GHS08 |
| Signal word | Danger |
| Hazard statements | H300+H330-H361f |
| Precautionary statements | P201-P202-P260-P264-P270-P304+P340+P310 |
| Safety Statements | 22-24/25 |
| RIDADR | 2811 |
| WGK Germany | 3 |
| RTECS | YK7751000 |
| HazardClass | 6.1 |
| PackingGroup | I |
| HS Code | 29321900 |
| Toxicity | LD50 i.p. in mice: 1.93 mg/kg (Chen) |
