Triptolide , Analysis of standard products, ≥98% , 38748-32-2

Synonym(s):
PG 490;PG490;Triptolide, Tripterygium wilfordii - CAS 38748-32-2 - Calbiochem

CAS NO.：38748-32-2

Empirical Formula: C20H24O6

Molecular Weight: 360.4

MDL number: MFCD00210565

EINECS: 683-214-2

PRODUCT Properties

• Melting point: 226-227°C
• alpha: D25 -154°
• Boiling point: 412.43°C (rough estimate)
• Density: 1.1656 (rough estimate)
• refractive index: 1.4450 (estimate)
• storage temp.: 2-8°C
• solubility: DMSO: soluble
• form: solid
• pka: 14.25±0.60(Predicted)
• color: white to off-white
• Merck: 14,9747
• Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
• InChIKey: DFBIRQPKNDILPW-CIVMWXNOSA-N
• CAS DataBase Reference: 38748-32-2(CAS DataBase Reference)
• EPA Substance Registry System: Trisoxireno[6,7:8a,9:4b,5]phenanthro[1,2-c]furan-1(3H)-one, 3b,4,4a,6,6a,7a,7b,8b,9,10-decahydro-6-hydroxy-8b-methyl-6a-(1-methylethyl)-, (3bS,4aS,5aS,6R,6aR,7aS,7bS,8aS,8bS)- (38748-32-2)

Description and Uses

Triptolide (38748-32-2) possesses potent immunosuppressive and anti-inflammatory activity.? Irreversibly inhibits eukaryotic transcription via covalent binding to XPB, a subunit of the transcription factor TFIIH.1??Blocks transactivation of NFkB.2?Exhibits potent antiproliferative activity in 60 cancer cell lines (average IC50?= 12 nM) and synergizes with other anticancer agents.3?Inhibits the inflammatory response and remarkably decreases production of TNF-a, IL-1b and IL-6 in a rat model of rheumatoid arthritis.4

Triptolide is a diterpenoid triepoxide with immunosuppressant and antitumor properties.

Safety

• Symbol(GHS): GHS06,GHS08
• Signal word: Danger
• Hazard statements: H300+H330-H361f
• Precautionary statements: P201-P202-P260-P264-P270-P304+P340+P310
• Safety Statements: 22-24/25
• RIDADR: 2811
• WGK Germany: 3
• RTECS: YK7751000
• HazardClass: 6.1
• PackingGroup: I
• HS Code: 29321900
• Toxicity: LD50 i.p. in mice: 1.93 mg/kg (Chen)