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A7101612

Quetiapine Fumarate , ≥98% , 111974-72-2

Synonym(s):
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate;Quetiapine fumarate;Quetiapine hemifumarate salt

CAS NO.:111974-72-2

Empirical Formula: C46H54N6O8S2

Molecular Weight: 883.09

MDL number: MFCD03423782

EINECS: 1308068-626-2

Pack Size Price Stock Quantity
1G RMB42.40 In Stock
5G RMB118.40 In Stock
10g RMB222.40 In Stock
25G RMB575.20 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 174-176°C
Flash point: 9℃
storage temp.  2-8°C
solubility  DMSO: >10mg/mL
form  powder
color  white to off-white
Merck  14,8039
BCS Class 2
Stability: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey VRHJBWUIWQOFLF-WLHGVMLRSA-N
SMILES C(/C(=O)O)=C\C(=O)O.C(N1CCN(C2=NC3C=CC=CC=3SC3=CC=CC=C23)CC1)COCCO
CAS DataBase Reference 111974-72-2(CAS DataBase Reference)

Description and Uses

Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively.2 Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model.3 Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.4

Quetiapine hemifumarate salt has been used as an antagonist for β-arrestin 2 mutant T205M recruitment.

Safety

Symbol(GHS) 
GHS07,GHS09
Signal word  Warning
Hazard statements  H302-H400
Precautionary statements  P273-P301+P312+P330
Hazard Codes  Xn,N,T,F
Risk Statements  22-50/53-52/53-39/23/24/25-23/24/25-11
Safety Statements  60-61-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  KK3605000
HS Code  29349990

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