A7101612
Quetiapine Fumarate , ≥98% , 111974-72-2
Synonym(s):
2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethanol hemifumarate;Quetiapine fumarate;Quetiapine hemifumarate salt
CAS NO.:111974-72-2
Empirical Formula: C46H54N6O8S2
Molecular Weight: 883.09
MDL number: MFCD03423782
EINECS: 1308068-626-2
Pack Size | Price | Stock | Quantity |
1G | RMB42.40 | In Stock |
|
5G | RMB118.40 | In Stock |
|
10g | RMB222.40 | In Stock |
|
25G | RMB575.20 | In Stock |
|
others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
Melting point: | 174-176°C |
Flash point: | 9℃ |
storage temp. | 2-8°C |
solubility | DMSO: >10mg/mL |
form | powder |
color | white to off-white |
Merck | 14,8039 |
BCS Class | 2 |
Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
InChIKey | VRHJBWUIWQOFLF-WLHGVMLRSA-N |
SMILES | C(/C(=O)O)=C\C(=O)O.C(N1CCN(C2=NC3C=CC=CC=3SC3=CC=CC=C23)CC1)COCCO |
CAS DataBase Reference | 111974-72-2(CAS DataBase Reference) |
Description and Uses
Quetiapine hemifumarate (111974-72-2) is an atypical antipsychotic agent. Antagonist at serotonin (5-HT2) and dopamine (D2) receptors, IC50s=148 and 329 nM respectively.2 Reverses depressive-like behavior and reduces DNA methyltransferase activity induced by maternal deprivation in a rat model.3 Efficacious as a monotherapy in the treatment of posttraumatic stress disorder.4
Quetiapine hemifumarate salt has been used as an antagonist for β-arrestin 2 mutant T205M recruitment.
Safety
Symbol(GHS) | GHS07,GHS09 |
Signal word | Warning |
Hazard statements | H302-H400 |
Precautionary statements | P273-P301+P312+P330 |
Hazard Codes | Xn,N,T,F |
Risk Statements | 22-50/53-52/53-39/23/24/25-23/24/25-11 |
Safety Statements | 60-61-45-36/37-16 |
RIDADR | UN1230 - class 3 - PG 2 - Methanol, solution |
WGK Germany | 3 |
RTECS | KK3605000 |
HS Code | 29349990 |