Brazilin , 10mMinDMSO , 474-07-7

Synonym(s):
(+)-Brazilin;(6aS,11bR)-7,11b-Dihydro-benz[b]indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol;6,6a,7,11b-Tetrahydro-3,6a,9,10-tetrahydroxyindeno[2,1-c]chromene;7, 11b-dihydrobenz[b]indeno[1,2-d]pyran-3,6a,9,10 (6H)-tetrol;Brasilin

CAS NO.：474-07-7

Empirical Formula: C16H14O5

Molecular Weight: 286.28

MDL number: MFCD00210817

EINECS: 207-477-6

PRODUCT Properties

• Melting point: 156-157℃
• Boiling point: 348.65°C (rough estimate)
• Density: 1.1924 (rough estimate)
• refractive index: 1.6200 (estimate)
• solubility: DMSO:43.5(Max Conc. mg/mL);151.95(Max Conc. mM); DMF:30.0(Max Conc. mg/mL);104.79(Max Conc. mM); Ethanol:30.0(Max Conc. mg/mL);104.79(Max Conc. mM); PBS (pH 7.2):10.0(Max Conc. mg/mL);34.93(Max Conc. mM)
• form: A crystalline solid
• color: Yellow to brown

Description and Uses

Brazilin is an isoflavonoid originally isolated from C. sappan that has diverse biological activities, including neuroprotective, anti-inflammatory, antibacterial, and antioxidant properties. Brazilin inhibits Aβ (1-42) fibrillogenesis (IC₅₀ = 1.5 μM) more potently than (-)-epigallocatechin gallate , cucurmin , and resveratrol (Item Nos. 10004235 | 70675). It also prevents remodeling of mature Aβ (1-42) fibrils. Brazilin inhibits the production of cytokines, including PGE₂ and TNF-α (IC₅₀s = 12.6 and 87.2 μM). It is effective against Gram-positive and Gram-negative bacteria with MICs ranging from 31.3 to 250 μg/ml. In addition, brazilin inhibits osteoclast differentiation mediated by RANKL and is protective against LPS-induced osteoporosis in mice at a dose of 100 mg/kg.

Chiefly as a dye. Has also been recommended as indicator in acid-base titrations; acids = yellow, alkalies = carmine-red.

Safety

• Symbol(GHS): GHS07
• Signal word: Warning
• Hazard statements: H315-H319-H335
• Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338
• Safety Statements: 24/25
• HS Code: 29329990