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A2370812

Curcumol , Analysis of standard products, ≥98% , 4871-97-0

Synonym(s):
(−)-Curcumol;(3S,3aS,5S,6R,8aS)-Octahydro-3-methyl-8-methylene-5-(1-methylethyl)-6H-3a,6-epoxyazulen-6-ol

CAS NO.:4871-97-0

Empirical Formula: C15H24O2

Molecular Weight: 236.35

MDL number: MFCD00272163

Pack Size Price Stock Quantity
20MG RMB240.00 In Stock
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Update time: 2022-07-08

PRODUCT Properties

Melting point: 141.0 to 145.0 °C
Boiling point: 334.5±42.0 °C(Predicted)
Density  1.06±0.1 g/cm3(Predicted)
storage temp.  under inert gas (nitrogen or Argon) at 2–8 °C
solubility  DMSO:55.67(Max Conc. mg/mL);235.54(Max Conc. mM)
DMF:20.0(Max Conc. mg/mL);84.62(Max Conc. mM)
Ethanol:28.5(Max Conc. mg/mL);120.58(Max Conc. mM)
pka 13.02±0.60(Predicted)
form  Solid
color  White to Light yellow
InChI InChI=1S/C15H24O2/c1-9(2)13-8-14-11(4)5-6-12(14)10(3)7-15(13,16)17-14/h9,11-13,16H,3,5-8H2,1-2,4H3/t11-,12-,13-,14-,15+/m0/s1
InChIKey QRMPRVXWPCLVNI-YYFQZIEXSA-N
SMILES C1[C@]2([H])[C@@]3(O[C@](O)(CC2=C)[C@H](C(C)C)C3)[C@@H](C)C1
LogP 3.276 (est)

Description and Uses

Curcumol, a bioactive sesquiterpenoid, has been isolated from various plants from Zingiberaceae. In recent years, curcumol attracts much attention due to its multiple biological activities and few negative effects. Accumulated studies prove that curcumol shows beneficial effects in protecting against inflammation, oxidative stress, cancer, neurodegeneration and microbial infection. Besides, a number of signaling pathways such as MAPK, PI3K/Akt and NF-κB are influenced by curcumol[2].

Curcumol is a potential treatment for advanced hepatocellular carcinoma (HCC). It can be used as a chemotherapeutic sensitiser in order to enhance the anti-tumour effect of chemotherapeutic drugs. Studies have shown that it promotes HCC cell apoptosis in vitro and inhibits HCC tumour growth in vivo. It combined with lenvatinib can induce more autolysosome formation, which can enhance the anti-tumour effect of lenvatinib on hepatocellular carcinoma cells.

Safety

WGK Germany  3
HS Code  29321900

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