A7044558
BIIB021 , 10mMinDMSO , 848695-25-0
CAS NO.：848695-25-0
Empirical Formula: C14H15ClN6O
Molecular Weight: 318.76
MDL number: MFCD15528939
EINECS: 812-781-2
| Pack Size | Price | Stock | Quantity |
| 1ml | RMB399.20 | In Stock |
|
| others | Enquire |
Update time: 2022-07-08
PRODUCT Properties
| Melting point: | 192-193℃ |
| Boiling point: | 588.5±60.0 °C(Predicted) |
| Density | 1.50 |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (>25 mg/ml) |
| form | solid |
| pka | 6.07±0.40(Predicted) |
| color | White |
| Stability: | Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha. |
Description and Uses
BIIB021 is a potent HSP90 inhibitor (IC50 = 30 nM HER-2 degradation).1 It inhibited the proliferation of MCF7 and BT474 breast cancer cell lines (IC50 = 100 nM for each).? BIIB021 has shown efficacy as a therapeutic in multiple cancer models.2-5
BIIB 021 an orally available, fully synthetic small-molecule inhibitor of the heat shock protein Hsp90. Studies show that BIIB 021 adminisitration led to degradation of Hsp90 client proteins measured in tumor tissue and resulted in the inhibition of tumor growth in several human tumor xenograft models.
Safety
| Symbol(GHS) |  GHS07 |
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P261-P271-P280 |
| HS Code | 2921490090 |
